Research project

The role of Factor inhibiting HIF (FIH) in the development of idiopathic pulmonary fibrosis (IPF)

Research groups:
Lead researcher:

Dr Yihua Wang
Research funder:

The Academy of Medical Sciences
Status:

Not active

Staff

Lead researcher

Dr Yihua Wang

Associate Professor

Research interests

Cell Signalling in Disease
Epithelial-Mesenchymal Crosstalk
Pulmonary Fibrosis

Connect with Yihua

Email: yihua.wang@soton.ac.uk

Collaborating research institutes, centres and groups

Cell and Developmental Biology

We explore how molecular interactions between proteins and small molecules, defined at atomic resolution, govern biochemical output and in turn control cell behaviour.

Research outputs

Paracrine signalling during ZEB1-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in lung fibrosis.

Liudi Yao, Franco Conforti, Charlotte Hill, Joseph Bell, Leena Drawater, Juanjuan Li, Dian Liu, Hua Xiong, Aiman Alzetani, Serena J. Chee, Ben G. Marshall, Sophie V. Fletcher, David Hancock, Mark Coldwell, Xianglin Yuan, Christian H. Ottensmeier, Julian Downward, Jane E. Collins, Rob M. Ewing, Luca Richeldi, Paul Skipp, Mark G. Jones, Donna E. Davies & Yihua Wang, 2018, Cell Death and Differentiation, 26(5), 943-957

DOI: 10.1038/s41418-018-0175-7

Type: article