Research project

The role of Factor inhibiting HIF (FIH) in the development of idiopathic pulmonary fibrosis (IPF)

Research groups:
Lead researcher:

Dr Yihua Wang
Research funder:

The Academy of Medical Sciences
Status:

Not active

Staff

Lead researcher

Dr Yihua Wang

Associate Professor

Research interests

Cell Signalling in Disease
Epithelial-Mesenchymal Crosstalk
Pulmonary Fibrosis

Connect with Yihua

Email: yihua.wang@soton.ac.uk

Collaborating research institutes, centres and groups

Cell and Developmental Biology

We explore how molecular interactions between proteins and small molecules, defined at atomic resolution, govern biochemical output and in turn control cell behaviour.

Research outputs

WDHD1 is essential for the survival of PTEN-inactive triple negative breast cancer

Ayse Ertay, Huiquan Liu, Dian Liu, Ping Peng, Charlotte Hill, Hua Xiong, David Hancock, Xianglin Yuan, Marcin Przewloka, Mark Coldwell, Michael Howell, Paul Skipp, Robert Ewing, Julian Downward & Yihua Wang, 2020, Cell Death and Disease

DOI: 10.1038/s41419-020-03210-5

Type: article

Paracrine SPARC signaling dysregulates alveolar epithelial barrier integrity and function in lung fibrosis

Franco Conforti, Robert Ridley, Christopher J Brereton, Aiman Alzetani, Mark Jones, Donna Davies, Paul Skipp, Yihua Wang, Christian Ottensmeier, B. Marshall, Sophie Fletcher, Luca Richeldi & Benjamin Johnson, 2020, Cell Death and Discovery, 6

DOI: 10.1038/s41420-020-0289-9

Type: article

Viral infection increases the risk of idiopathic pulmonary fibrosis: A meta-analysis

Gaohong Sheng, Peng Chen, Yanqiu Wei, Huihui Yue, Jiaojiao Chu, Jianping Zhao, Yihua Wang, Wanguang Zhang & Hui-Lan Zhang, 2020, Chest, 157(5), 1175-1187

DOI: 10.1016/j.chest.2019.10.032

Type: article

ASPP1 deficiency promotes epithelial-mesenchymal transition, invasion and metastasis in colorectal cancer

Dian Liu, Ayse Ertay, Charlotte Hill, Yilu Zhou, Juanjuan Li, Yanmei Zou, Hong Qiu, Xianglin Yuan, Robert Ewing, Xin Lu, Hua Xiong & Yihua Wang, 2020, Cell Death and Disease, 11(4)

DOI: 10.1038/s41419-020-2415-2

Type: article

Deconvolution of RNA-seq analysis of hyperbaric oxygen-treated mice lungs reveals mesenchymal cell subtype changes

Yuan Yuan, Yilu Zhou, Yali Li, Charlotte Hill, Robert Ewing, Mark Jones, Donna Davies, Zhenglin Jiang & Yihua Wang, 2020, International Journal of Molecular Sciences, 21(4), 1-19

DOI: 10.3390/ijms21041371

Type: article