Research project

The role of Factor inhibiting HIF (FIH) in the development of idiopathic pulmonary fibrosis (IPF)

Research groups:
Lead researcher:

Dr Yihua Wang
Research funder:

The Academy of Medical Sciences
Status:

Not active

Staff

Lead researcher

Dr Yihua Wang

Associate Professor

Research interests

Cell Signalling in Disease
Epithelial-Mesenchymal Crosstalk
Pulmonary Fibrosis

Connect with Yihua

Email: yihua.wang@soton.ac.uk

Collaborating research institutes, centres and groups

Cell and Developmental Biology

We explore how molecular interactions between proteins and small molecules, defined at atomic resolution, govern biochemical output and in turn control cell behaviour.

Research outputs

Autophagy inhibition-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis

Charlotte Hill, Juanjuan Li, Dian Liu, Franco Conforti, Christopher J. Brereton, Liudi Yao, Yilu Zhou, Aiman Alzetani, Serena J. Chee, Ben G. Marshall, Sophie V. Fletcher, David Hancock, Christian H. Ottensmeier, Andrew J. Steele, Julian Downward, Luca Richeldi, Xin Lu, Donna E. Davies, Mark G. Jones & Yihua Wang, 2019, Cell Death and Disease, 10(8)

DOI: 10.1038/s41419-019-1820-x

Type: article

SGLT1 is required for the survival of triple negative breast cancer cells via potentiation of EGFR activity

Huiquan Liu, Ayse Ertay, Ping Peng, Juanjuan Li, Dian Liu, Hua Xiong, Yanmei Zou, Hong Qiu, David Hancock, Xianglin Yuan, Wei-Chien Huang, Robert Ewing, Julian Downward & Yihua Wang, 2019, Molecular Oncology

DOI: 10.1002/1878-0261.12530

Type: article

Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells

Yihua Wang, Hua Xiong, Dian Liu, Charlotte Hill, Ayse Ertay, Juanjuan Li, Yanmei Zou, Paul Miller, Eileen White, Julian Downward, Robert Goldin, Xianglin Yuan & Xin Lu, 2019, Autophagy, 15(5), 886-899

DOI: 10.1080/15548627.2019.1569912

Type: article

Nuclear entry and export of FIH are mediated by HIF1α and exportin1, respectively

Yihua Wang, Shan Zhong, Christopher J. Schofield, Peter J. Ratcliffe & Xin Lu, 2018, Journal of Cell Science, 131(22), 1-8

DOI: 10.1242/jcs.219782

Type: article

ELF3 is an antagonist of oncogenic-signalling-induced expression of EMT-TF ZEB1

D. Liu, Y. Skomorovska, J. Song, E. Bowler, R. Harris, M. Ravasz, S. Bai, M. Ayati, K. Tamai, M. Koyuturk, X. Yuan, Z. Wang, Y. Wang & R.M. Ewing, 2018, Cancer Biology & Therapy, 1-11

DOI: 10.1080/15384047.2018.1507256

Type: article