Research project

Long-lived Nuclear Hyperpolarization of Methyl Groups

Research groups:

Organic Chemistry, Synthesis, Catalysis
Lead researcher:

Professor Malcolm Levitt
Other researchers:

Professor Richard Brown
Research funder:

EPSRC
Status:

Not active

Project overview

This project consists of the hyperpolarization of long-lived states in methyl groups and their isotopomers. The project makes use of solution NMR and dissolution-DNP equipment.

Staff

Lead researcher

Professor Malcolm Levitt

Professor of Chemistry

Research interests

Magnetic Resonance
Endofullerenes

Connect with Malcolm

Email: mhl@soton.ac.uk

Other researchers

Professor Richard Brown

Professor of Organic Chemistry

Research interests

Organic synthesis
Total synthesis of natural products
Asymmetric synthesis

Connect with Richard

Email: R.C.Brown@soton.ac.uk

Collaborating research institutes, centres and groups

Magnetic Resonance

Our main focus is finding ways to extend the timescale over which magnetic resonance can be made.

Organic Chemistry, Synthesis, Catalysis

We develop environmentally sustainable approaches to chemical manufacture that minimise chemical waste, improve product velocity and reduce the need to isolate intermediates.

Research outputs

Singlet NMR methodology in two-spin-1/2 systems

Giuseppe Pileio, 2017, Progress in Nuclear Magnetic Resonance Spectroscopy, 98-99, 1-19

DOI: 10.1016/j.pnmrs.2016.11.002

Type: article

Singlet order conversion and parahydrogen-induced hyperpolarization of 13C nuclei in near-equivalent spin systems

James Eills, Gabriele Stevanato, Christian Bengs, Stefan Gloggler, Stuart Elliott, Javier Alonso Valdesueiro, Giuseppe Pileio & Malcolm Levitt, 2017, Journal of Magnetic Resonance, 274, 163-172

DOI: 10.1016/j.jmr.2016.11.010

Type: article

Versatile magnetic resonance singlet tags compatible with biological conditions

Stefan Gloggler, Stuart Elliott, Gabriele Stevanato, Richard C.D. Brown & Malcolm H. Levitt, 2017, RSC Advances, 7(55), 34574-34578

DOI: 10.1039/C7RA05196D

Type: article

Long-lived nuclear spin states in rapidly rotating CH2D groups

Stuart Elliott, Lynda J. Brown, Jean-Nicolas Dumez & Malcolm H. Levitt, 2016, Journal of Magnetic Resonance, 272, 87-90

DOI: 10.1016/j.jmr.2016.09.009

Type: article

Long-lived nuclear spin states in monodeuterated methyl groups

Stuart Elliott, Lynda J. Brown, Jean-Nicolas Dumez & Malcolm H. Levitt, 2016, Physical Chemistry Chemical Physics, 18(27), 17965-17972

DOI: 10.1039/C6CP03619H

Type: article