View all research projects
Research project

Long-lived Nuclear Hyperpolarization of Methyl Groups

Project overview

This project consists of the hyperpolarization of long-lived states in methyl groups and their isotopomers. The project makes use of solution NMR and dissolution-DNP equipment.

Staff

Lead researcher

Professor Malcolm Levitt

Professor of Chemistry

Research interests

  • Magnetic Resonance
  • Endofullerenes
Connect with Malcolm

Email: mhl@soton.ac.uk

Other researchers

Professor Richard Brown

Professor of Organic Chemistry

Research interests

  • Organic synthesis
  • Total synthesis of natural products
  • Asymmetric synthesis
Connect with Richard

Email: R.C.Brown@soton.ac.uk

Collaborating research institutes, centres and groups

Magnetic Resonance

Our main focus is finding ways to extend the timescale over which magnetic resonance can be made.

Organic Chemistry, Synthesis, Catalysis

We develop environmentally sustainable approaches to chemical manufacture that minimise chemical waste, improve product velocity and reduce the need to isolate intermediates.

Research outputs

Testing signal enhancement mechanisms in the dissolution NMR of acetone
Javier Alonso-Valdesueiro, Stuart Elliott, Christian Bengs, Benno Meier & Malcolm H. Levitt, 2018, Journal of Magnetic Resonance, 286, 158-162
DOI: 10.1016/j.jmr.2017.12.009
Type: article
Hyperpolarized long-lived nuclear spin states in monodeuterated methyl groups
Stuart J. Elliott, Benno Meier, Basile Vuichoud, Gabriele Stevanato, Lynda J. Brown, Javier Alonso-Valdesueiro, Lyndon Emsley, Sami Jannin & Malcolm H. Levitt, 2018, Physical Chemistry Chemical Physics, 20(15), 9755-9759
DOI: 10.1039/c8cp00253c
Type: article
Dynamic nuclear polarization of long-lived nuclear spin states in methyl groups
Jean-Nicolas Dumez, Basile Vuichoud, Daniele Mammoli, Aurélien Bornet, Arthur C. Pinon, Gabriele Stevanato, Benno Meier, Geoffery Bodenhausen, Sami Jannin & Malcolm H. Levitt, 2017, The Journal of Physical Chemistry Letters, 8(15), 3549-3555
DOI: 10.1021/acs.jpclett.7b01512
Type: article
Origins of small proton chemical shift differences in monodeuterated methyl groups
O. Maduka Ogba, Stuart Elliott, David A. Kolin, Lynda J. Brown, Sebastian Cevallos, Stuart Sawyer, Malcolm H. Levitt & Daniel J. O'Leary, 2017, The Journal of Organic Chemistry, 82(17), 8943–8949
DOI: 10.1021/acs.joc.7b01356
Type: article
NMR of molecular endofullerenes dissolved in a nematic liquid crystal
Karel Kouril, Christopher Wickens, Benno Meier, Shamim Alom, John Grasvik, Richard J. Whitby & Malcolm H. Levitt, 2017, Physical Chemistry Chemical Physics, 2017(19), 11793-11801
DOI: 10.1039/C7CP00906B
Type: article