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Research project

Long-lived Nuclear Hyperpolarization of Methyl Groups

Project overview

This project consists of the hyperpolarization of long-lived states in methyl groups and their isotopomers. The project makes use of solution NMR and dissolution-DNP equipment.

Staff

Lead researcher

Professor Malcolm Levitt

Professor of Chemistry

Research interests

  • Magnetic Resonance
  • Endofullerenes
Connect with Malcolm

Email: mhl@soton.ac.uk

Other researchers

Professor Richard Brown

Professor of Organic Chemistry

Research interests

  • Organic synthesis
  • Total synthesis of natural products
  • Asymmetric synthesis
Connect with Richard

Email: R.C.Brown@soton.ac.uk

Collaborating research institutes, centres and groups

Magnetic Resonance

Our main focus is finding ways to extend the timescale over which magnetic resonance can be made.

Organic Chemistry, Synthesis, Catalysis

We develop environmentally sustainable approaches to chemical manufacture that minimise chemical waste, improve product velocity and reduce the need to isolate intermediates.

Research outputs

NMR of 133Cs+ in stretched hydrogels: one-dimensional, z- and NOESY spectra, and probing the ion’s environment in erythrocytes
Philip W. Kuchel, Dmitry Shishmarev, Max Puckeridge, Malcolm Levitt, Christoph Naumann & Bogdan E. Chapman, 2015, Journal of Magnetic Resonance, 261, 110-120
DOI: 10.1016/j.jmr.2015.10.011
Type: article
Symmetry constraints on spin dynamics: application to hyperpolarized NMR
Malcolm H. Levitt, 2015, Journal of Magnetic Resonance, 1-9
DOI: 10.1016/j.jmr.2015.08.021
Type: article
Letter. Synthesis of an isotopically labeled naphthalene derivative that supports a long-lived nuclear singlet state
Joseph Hill-Cousins, Ionut-Alexandru Pop, Giuseppe Pileio, Gabriele Stevanato, Par Hakansson, Soumya Singha Roy, Malcolm Levitt, Lynda Brown & Richard Brown, 2015, Organic Letters, 17(9), 2150-2153
DOI: 10.1021/acs.orglett.5b00744
Type: article
A nuclear singlet lifetime of more than one hour in room-temperature solution
Gabriele Stevanato, Joseph T. Hill-Cousins, Pär Håkansson, Soumya Singha Roy, Lynda J. Brown, Richard C.D. Brown, Giuseppe Pileio & Malcolm H. Levitt, 2015, Angewandte Chemie International Edition, 54(12), 3740-3743
DOI: 10.1002/anie.201411978
Type: article
Theory of long-lived nuclear spin states in methyl groups and quantum-rotor induced polarisation
Jean-Nicolas Dumez, Par Hakansson, Salvo Mamone, Benno Meier, Gabriele Stevanato, Joseph Hill-Cousins, Soumya Singha Roy, Richard Brown, Giuseppe Pileio & Malcolm Levitt, 2015, The Journal of Chemical Physics, 142(4), 1-13
DOI: 10.1063/1.4906273
Type: article