Project overview
This application aims to determine: early biomarkers of cardiovascular disease (CVD) risk at birth/during childhood; the window(s) when early life interventions to reduce the risk of obesity and CVD are most effective; and the nature of potentially effective intervention(s). In the Southampton Women's Survey (SWS) prospective preconception cohort, we have discovered perinatal epigenetic biomarkers of later CVD risk in mechanistically relevant genes, now confirmed in our other cohorts. We will determine how these biomarkers relate to the trajectory of adiposity, cardiovascular structure, function and fitness in SWS children to age 12yrs. Using SWS samples collected at birth and age 12yrs we will extend our panel of epigenetic biomarkers and investigate interactions with fixed genetic variants in relation to CVD risk. Then we will relate the resulting biomarker panel to CVD risk in children from ongoing cohorts in which pre- or post-natal interventions to modify risk factors are being made.
Staff
Lead researchers
Other researchers
Collaborating research institutes, centres and groups
Research outputs
Keith Godfrey, Sheila Barton, Sarah El-Heis, Timothy Kenealy, Heidi Nield, Philip N. Baker, Yap-Seng Chong, Wayne Cutfield & Shiao-Yng Chan,
2021, Diabetes Care, 44(5), 1091-1099
DOI: 10.2337/dc20-2515
Type: article
Ray Sugianto, Jia Ying Toh, Shu Fang Wong, M.T. Tint, Marjorelee T. Colega, Y.S. Lee, Fabian Yap, Lynette P. Shek, K.H. Tan, Keith Godfrey, Y-S Chong, B.C. Tai & Mary Foong-Fong Chong,
2021, British Journal of Nutrition
Type: article
Shirong Cai, Izzuddin M. Aris, Wen Lun Yuan, Kok Hian Tan, Keith Godfrey, Peter D. Gluckman, Lynette Pei-Chi Shek , Yap-Seng Chong, Fabian Yap, Marielle V. Fortier, Michael J. Meaney, Yung Seng Lee & Anqi Qiu,
2021, BMJ Open, 9(1)
Type: article
Elie Antoun, Philip Titcombe, Kathryn V. Dalrymple, Negusse Kitaba, Sheila Barton, A.C. Flynn, Robert Murray, Emma Garratt, Paul T. Seed, Sara L. White, Cyrus Cooper, Hazel Inskip, Mark Hanson, L. Poston, Keith Godfrey & Karen Lillycrop,
2021, Epigenetics
Type: article
R.C. Huang, P.E. Melton, M.A. Burton, L.J. Beilin, R. Clarke-Harris, E. Cook, K.M. Godfrey, G.C. Burdge, T.A. Mori, D Anderson , S. Rauschert, J.M. Craig, M.S. Kobor, J.L. MacIsaac, A.M. Morin, W.H. Oddy, C.E. Pennell, J.D. Holbrook & K.A. Lillycrop,
2021, Epigenetics
Type: article
Anne H.Y. Chu & Keith Godfrey,
2021, Annals of Nutrition and Metabolism
DOI: 10.1159/000509902
Type: article
Neena Modi, Gabriella Conti & Mark Hanson,
2021, Archives of Disease in Childhood, 0, 1-2
Type: letterEditorial