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Research project

R Carare - Physiology of Perivascular drainage of the brain and how it is affected by advancing age

Staff

Lead researchers

Professor Roxi Carare

Head of School

Research interests

  • Causes and new therapeutic strategies for dementias and other neurodegenerative diseases
  • New early diagnostic measures in dementia based on biomarkers from the nose
  • Drug delivery to the brain
Connect with Roxi

Email: R.O.Carare@soton.ac.uk

Other researchers

Professor James Nicoll

Connect with James

Email: J.Nicoll@soton.ac.uk

Research outputs

The fine anatomy of the perivascular compartment in the human brain
Matthew MacGregor Sharp, Diederik Bulters, Sebastian Brandner, Janice Holton, Ajay Verma, David J. Werring & Roxana O. Carare, 2019, Neuropathology and Applied Neurobiology, 45(3), 305-308
DOI: 10.1111/nan.12480
Type: article
Loss of Clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways
Aleksandra Wojtas, Silvia Kang, Benjamin Olley, Maureen Gatherer, Mitsuru Shinohara, Patricia Lozano, Chia-Chen Liu, Aishe Kurti, Kelsey Baker, Dennis Dickson, Mei Yue, Leonard Petrucelli, Guojun Bu, Roxana Carare & John D. Fryer, 2017, Proceedings of National Academy of Sciences of the United States of America, 114(33), E6962-E6971
DOI: 10.1073/pnas.1701137114
Type: article
Deposition of amyloid-beta in the walls of human leptomeningeal arteries in relation to perivascular drainage pathways in cerebral amyloid angiopathy
Abby Keable, Kate Fenna, Ho Ming Yuen, David A. Johnston, Neil R. Smyth, Colin Smith, Rustam Al-Shahi Salman, Neshika Samarasekera, James A.R. Nicoll, Johannes Attems, Rajesh N. Kalaria, Roy O. Weller & Roxana-Octavia Carare, 2016, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1862(5), 1037-1046
DOI: 10.1016/j.bbadis.2015.08.024
Type: article
Quantification of molecular interactions between ApoE, amyloid-beta (A?) and laminin: relevance to accumulation of A? in Alzheimer's disease
Jurgita Zekonyte, Kenji Sakai, James A.R. Nicoll, Roy O. Weller & Roxana O. Carare, 2016, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1862(5), 1047-1053
DOI: 10.1016/j.bbadis.2015.08.025
Type: article
Vascular basement membranes as pathways for the passage of fluid into and out of the brain
Alan W.J. Morris, Matthew MacGregor Sharp, Nazira J. Albargothy, Rute Fernandes, Cheryl A Hawkes, Ajay Verma, Roy O Weller & Roxana O. Carare, 2016, Acta Neuropathologica, 131(5), 725-736
DOI: 10.1007/s00401-016-1555-z
Type: article