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Research project

Defining the role of ZEB1-dependent epithelial-mesenchymal crosstalk in lung fibrosis

  • Research groups:
  • Lead researchers:
    Dr Yihua Wang
  • Research funder:
    Medical Research Council
  • Status:
    Not active

Project overview

Idiopathic pulmonary fibrosis (IPF) is a life-threatening condition of the lungs where tissue becomes thickened, stiff, and scarred, limiting the amount of oxygen getting into the blood. The aim of this project is to provide effective targeted therapies for sufferers to reduce symptoms of this devastating disease and improve their quality of life as well as to identify biomarkers for IPF patients.

Staff

Lead researchers

Dr Yihua Wang

Associate Professor

Research interests

  • Cell Signalling in Disease
  • Epithelial-Mesenchymal Crosstalk
  • Pulmonary Fibrosis
Connect with Yihua

Email: yihua.wang@soton.ac.uk

Collaborating research institutes, centres and groups

Research outputs

Quantitative Proteomic Analysis in Alveolar Type II Cells Reveals the Different Capacities of RAS and TGF-β to Induce Epithelial–Mesenchymal Transition
Yilu Zhou, Charlotte Hill, Liudi Yao, Juanjuan Li, David Hancock, Julian Downward, Mark Jones, Donna Davies, Robert Ewing, Paul Skipp & Yihua Wang, 2021, Frontiers in Molecular Biosciences, 8
DOI: 10.3389/fmolb.2021.595712
Type: article
Temporal radiographic changes in COVID-19 patients: relationship to disease severity and viral clearance
Xiaofan Liu, Hong Zhou, Yilu Zhou, Xiaojun Wu, Yang Zhao, Yang Lu, Weijun Tan, Mingli Yuan, Xuhong Ding, Jinjing Zou, Ruiyun Li, Hailing Li, Robert Ewing, Yi Hu, Hanxiang Nie & Yihua Wang, 2020, Scientific Reports, 10(1)
DOI: 10.1038/s41598-020-66895-w
Type: article
WDHD1 is essential for the survival of PTEN-inactive triple negative breast cancer
Ayse Ertay, Huiquan Liu, Dian Liu, Ping Peng, Charlotte Hill, Hua Xiong, David Hancock, Xianglin Yuan, Marcin Przewloka, Mark Coldwell, Michael Howell, Paul Skipp, Robert Ewing, Julian Downward & Yihua Wang, 2020, Cell Death and Disease
DOI: 10.1038/s41419-020-03210-5
Type: article
Different laboratory abnormalities in COVID-19 patients with hypertension or diabetes
Xiaojun Wu, Tong Wang, Yilu Zhou, Xiaofan Liu, Hong Zhou, Yang Lu, Weijun Tan, Mingli Yuan, Xuhong Ding, Jinjing Zou, Ruiyun Li, Hailing Liu, Robert Ewing, Yi Hu, Hanxiang Nie & Yihua Wang, 2020, Virologica Sinica, 1-4
DOI: 10.1007/s12250-020-00296-1
Type: letterEditorial
Risk factors associated with disease severity and length of hospital stay in COVID-19 patients
Xiaofan Liu, Hong Zhou, Yilu Zhou, Xiaojun Wu, Yang Zhao, Yang Lu, Weijun Tan, Mingli Yuan, Xuhong Ding, Jinjing Zou, Ruiyun Li, Hailing Liu, Robert Ewing, Yi Hu, Hanxiang Nie & Yihua Wang, 2020, Journal of Infection, 81(1), e95-e97
DOI: 10.1016/j.jinf.2020.04.008
Type: letterEditorial