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Research project

Defining the role of ZEB1-dependent epithelial-mesenchymal crosstalk in lung fibrosis

  • Research groups:
  • Lead researcher:
    Dr Yihua Wang
  • Research funder:
    Medical Research Council
  • Status:
    Not active

Project overview

Idiopathic pulmonary fibrosis (IPF) is a life-threatening condition of the lungs where tissue becomes thickened, stiff, and scarred, limiting the amount of oxygen getting into the blood. The aim of this project is to provide effective targeted therapies for sufferers to reduce symptoms of this devastating disease and improve their quality of life as well as to identify biomarkers for IPF patients.

Staff

Lead researcher

Dr Yihua Wang

Associate Professor

Research interests

  • Cell Signalling in Disease
  • Epithelial-Mesenchymal Crosstalk
  • Pulmonary Fibrosis
Connect with Yihua

Email: yihua.wang@soton.ac.uk

Collaborating research institutes, centres and groups

Cell and Developmental Biology

We explore how molecular interactions between proteins and small molecules, defined at atomic resolution, govern biochemical output and in turn control cell behaviour.

Research outputs

Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis
Christopher J. Brereton, Liudi Yao, Elizabeth R. Davies, Yilu Zhou, Milica Vukmirovic, Joseph A. Bell, Siyuan Wang, Robert A. Ridley, Lareb S.N. Dean, Orestis G. Andriotis, Franco Conforti, Lennart Brewitz, Soran Mohammed, Timothy Wallis, Ali Tavassoli, Rob M. Ewing, Aiman Alzetani, Benjamin G. Marshall, Sophie V. Fletcher, Philipp J. Thurner, Aurelie Fabre, Naftali Kaminski, Luca Richeldi, Atul Bhaskar, Christopher J. Schofield, Matthew Loxham, Donna E. Davies, Yihua Wang & Mark G. Jones, 2022, eLife, 11
DOI: 10.7554/eLife.69348
Type: article
Proteomic characterization of GSK3β knockout shows altered cell adhesion and metabolic pathway utilisation in colorectal cancer cells
Emily Bowler-Barnett, Francisco D. Martinez-Garcia, Matthew Sherwood, Ahood Aleidan, Steve John, Sara Weston, Yihua Wang, Nullin Divecha, Paul Skipp & Rob M. Ewing, 2021, PLoS ONE, 16(11), e0246707
DOI: 10.1371/journal.pone.0246707
Type: article
Respiratory outcomes in patients following COVID-19-related hospitalisation: a meta-analysis
Tao Guo, Fangfang Jiang, Yufei Liu, Yunpeng Zhao, Yiran Li & Yihua Wang, 2021, Frontiers in Molecular Biosciences, 8
DOI: 10.3389/fmolb.2021.750558
Type: article
Bidirectional epithelial-mesenchymal crosstalk provides self-sustaining profibrotic signals in pulmonary fibrosis
Liudi Yao, Yilu Zhou, Juanjuan Li, Leanne Wickens, Franco Conforti, Anna Simron Rattu, Fathima M Ibrahim, Aiman Alzetani, Benjamin Marshall, Sophie Fletcher, David Hancock, Timothy Wallis, Julian Downward, Robert Ewing, Luca Richeldi, Paul Skipp, Donna Davies, Mark Glynne Jones & Yihua Wang, 2021, Journal of Biological Chemistry, 297(3)
DOI: 10.1016/j.jbc.2021.101096
Type: article
3-month, 6-month, 9-month, and 12-month respiratory outcomes in patients following COVID-19-related hospitalisation: a prospective study
Xiaojun Wu, Xiaofan Liu, Yilu Zhou, Hongying Yu, Ruiyun Li, Qingyuan Zhan, Fang Ni, Si Fang, Yang Lu, Xuhong Ding, Hailing Liu, Robert Ewing, Mark Jones, Yi Hu, Hanxiang Nie & Yihua Wang, 2021, The Lancet Respiratory Medicine
DOI: 10.1016/S2213-2600(21)00174-0
Type: article