Research group

Interdisciplinary Musculoskeletal Health

4 Stained femur cross sections

The University hosts a substantial interdisciplinary community of researchers working to transform musculoskeletal health across the life course.

About

With expertise in regenerative medicine, physiology, engineering, orthopaedics, prosthetics and orthotics, rehabilitation and assistive technologies, epidemiology and clinical trial design, we aim to improve lives by delivering improved treatments, increasing the speed to market of musculoskeletal-focused technology and training the next generation of scientists and engineers. 

The population across the globe is living longer, which brings a number of healthcare challenges, especially in musculoskeletal health. The burden of age-related disease and injury is rising rapidly, having a detrimental impact on people’s quality of life and increasing the costs of healthcare provision. Loss of muscle mass and function is the leading reason for loss of independence in later life, and causes impaired mobility, falls, fractures, physical disability, increased insulin resistance and associated co-morbidities, and mortality. The number of hip fractures is expected to rise to 6.3 million by 2050 and the number of diabetic lower limb amputations has now risen to 7,000 per year in the UK and over 70,000 in the USA. 

The University is working to meet these challenges by creating networks of experts working in interdisciplinary musculoskeletal health research to develop new technologies, interventions and practices that will have a positive effect on people’s lives:

  • FortisNet is an interdisciplinary research network of clinical, academic and industrial partners that aims to develop products and services to transform musculoskeletal health. Launched in 2016, we have fostered over 50 new collaborations with other universities from across the UK, the NHS and industry. We have developed courses with national partners to help innovators understand how to bring medical technologies to market, and through investment in interdisciplinary studentships we are working to dissolve discipline boundaries, to train a new generation of life scientists and engineers for the benefit of society.
  • MyAge (Muscle resilience across the life course: from cells to society) is one of eleven UK Ageing Networks, funded by the Biotechnology and Biological Sciences Research Council and Medical Research Council. Led by the Institute for Life Sciences, together with partners from Birmingham, Nottingham and Imperial, the network will guide the future of muscle resilience research through roadmap development and interdisciplinary collaboration.

Research highlights

Preventing the transmission of non-communicable disease risk between generations

Research from the Developmental Origins of Health and Disease Centre demonstrates how the diet and lifestyle choices of prospective parents and pregnant mothers can affect the long-term health of their children.

Using nanoclay gel to regrow, repair and replace damaged cells

Southampton researchers have developed an innovative medical clay that can be used to apply regenerative medicine to patients with musculoskeletal conditions.

People, projects and publications

People

Professor Chris Hauton PhD, FRSB, FMBA

Head of School

Research interests

  • Hauton has worked extensively with colleagues in India and Bangladesh since 2015 and has developed an international profile in shrimp health research, including contributing to the development of a mobile phone app, the 'Chingri Shrimp App', to support shrimp farmer training in Bangladesh.
  • Research has also included quantifying the potential toxic risk of deep sea mining of mineral resources. He was part of the leading team of the EC FP7 MIDAS Project, exploring the ecological risk of deep-sea mining, outputs from which led to contributions to the Royal Society Foresight Future of the Sea report (2016/17), to presentations at the UN International Seabed Authority in Jamaica, and expert contributions to the UN ISA ISA Legal and Technical Commision ISBA/27/C/11 'Guidelines for the establishment of baseline environmental data.'
  • Other activity

Accepting applications from PhD students

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Dr Chris McCormick BSc, DPhil, PGCert

Associate Professor

Research interests

  • Positive strand RNA virus replication
  • Viral proteases
  • Viral host pathogen interactions

Accepting applications from PhD students

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Professor Chris Skylaris

Professor of Computational Chemistry

Research interests

  • Development of large-scale electronic structure methods, based on Density Functional Theory within the ONETEP program (onetep.org)
  • Development of atomistic and multiscale simulation methods for materials using quantum and classical methods, and machine-learned potentials
  • Application of these simulation methods to discover advanced materials in technologically relevant problems such as batteries, hydrogen fuel cells and drud optimisation

Accepting applications from PhD students

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Dr Chrissie Jones BMedSci, BMBS, FRCPCH, PgcertHBE, FHEA, PhD

Assoc Prof Paeds Infection & Immunology

Research interests

  • Vaccination in pregnancy
  • Infection risk reduction in pregnancy
  • Congenital infections

Accepting applications from PhD students

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Professor Christian Knigge

Professor of Astrophysics

Research interests

  • accretion phenomena and associated outflows
  • cataclysmic variables
  • close binaries
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Dr Christina Saville MSc, PhD, AFORS

Lecturer in Healthcare Management

Research interests

  • Safe staffing
  • Operational research techniques applied to healthcare
  • Health workforce
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Professor Christine Currie

Professor of Operational Research

Research interests

  • Simulation optimisation
  • Healthcare management
  • Decision making under uncertainty

Accepting applications from PhD students

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Dr Christoph Witzel

Associate Professor

Research interests

  • My main technical expertise is colour psychophysics and behavioural experiments.The main focus of my work has been the role of language and experience in colour perception.More broadly, I am interested in how culture and experience shape automatic assumptions to form our subjective reality.See also "About", and for recent developments and PhD opportunities, see Lab Website.

Accepting applications from PhD students

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Related research institutes, centres and groups

Related research institutes, centres and groups

Connect with us

We welcome new members. To join, or find out more about FortisNet or MyAge, please email the Institute for Life Sciences team.