Research group

BiOmics

Bar coded DNA sample

Technological advances have allowed scientists to gather large amounts of data about a vast array of species, organisms and single cells. Our researchers are using mathematical modelling, machine learning and other algorithms to extract information and patterns from large data sets to further our understanding of disease.

About

Contemporary scientific research benefits from rapid technological developments that enable the characterisation and quantification of biological molecules at unprecedented scale. Scientists can generate vast data that provide insight into the complex interplay of molecules within organisms. Interrogation and interpretation of these data inform the structure, function and interaction of molecules over time. 

We use ‘Omic technologies comprehensively to evaluate DNA (genomics), RNA (transcriptomics) and proteins (proteomics). We study small molecules using metabolomics. Microorganisms are investigated in a targeted manner using microbiomics or more broadly to characterise mixed samples using metagenomics.

At the University of Southampton, we generate vast datasets using these approaches across a wide range of environments and species. We work closely with NHS partners to use these capabilities to understand human disease and inform its clinical management. We bring together medical and biological scientists with mathematicians, computer and data scientists to develop and apply methods that exploit these data to their fullest potential.

From analysing patient genomes, to carrying out metagenomic analysis of water samples to using mass spectrometry metabolic profiling techniques, our scientists are studying the unique processes that take place within cells that can lead to disease or poor health outcomes in humans and help track changes in the environment.   

We are using data to answer clinical questions in areas such as cancer, autoimmune and respiratory diseases with the help of clinical colleagues we are translating our findings into novel techniques for clinicians to treat their patients, make predictions about prognosis and drug responsiveness.

Our researchers collaborate with partners at:

People, projects and publications

People

Professor Michael Boniface CEng, FIET

Professorial Fellow in Information Techn

Research interests

  • Artifical intelligence for health systems
  • Human centred interactive systems
  • Federated systems management 
Connect with Michael

Dr Michal Kalkowski PhD

Associate Professor

Research interests

  • Non-destructive testing
  • Material characterisation and imaging with ultrasound
  • Guided waves

Accepting applications from PhD students

Connect with Michal

Professor Mike Grocott BSc MBBS MD FRCA FRCP FFICM

Professor of Anaesthesia & Critical Care
Connect with Mike

Dr Mirella Cosma Spalluto PhD

Senior Research Fellow

Accepting applications from PhD students

Connect with Mirella Cosma

Professor Myron Christodoulides

Professor of Bacteriology

Accepting applications from PhD students

Connect with Myron

Dr Nathan Huneke MBChB MRes MRCPsych

NIHR Academic Clinical Lecturer

Research interests

  • Experimental medicine
  • Neuroimaging
  • Placebo and nocebo effects
Connect with Nathan

Dr Nazrul Islam MBBS, MSc, MPH, PhD

Associate Professor

Accepting applications from PhD students

Connect with Nazrul

Dr Neil J. Gostling BSc PhD FLS

Associate Professor

Research interests

  • Evolutionary Biology
  • Palaeobiology
  • Molecular Biology

Accepting applications from PhD students

Connect with Neil J.

Professor Neil White BSc, PhD, DSc, CEng, CPhys, FIET, FInstP, SMIEEE

Professor in Intelligent Sensor Systems

Research interests

  • Medical sensors
  • Intelligent sensor systemS
  • Energy harvesting

Accepting applications from PhD students

Connect with Neil
We are at a very exciting time in Life Science Research. The potential for novel discovery using ‘omics technologies combined with the computer science methodologies is immense.
Professor of Genomics

Related research institutes, centres and groups

Related research institutes, centres and groups

Contact us

Contact us

Contact the Institute for Life Sciences team by emailing: