Research group

BiOmics

Bar coded DNA sample

Technological advances have allowed scientists to gather large amounts of data about a vast array of species, organisms and single cells. Our researchers are using mathematical modelling, machine learning and other algorithms to extract information and patterns from large data sets to further our understanding of disease.

About

Contemporary scientific research benefits from rapid technological developments that enable the characterisation and quantification of biological molecules at unprecedented scale. Scientists can generate vast data that provide insight into the complex interplay of molecules within organisms. Interrogation and interpretation of these data inform the structure, function and interaction of molecules over time. 

We use ‘Omic technologies comprehensively to evaluate DNA (genomics), RNA (transcriptomics) and proteins (proteomics). We study small molecules using metabolomics. Microorganisms are investigated in a targeted manner using microbiomics or more broadly to characterise mixed samples using metagenomics.

At the University of Southampton, we generate vast datasets using these approaches across a wide range of environments and species. We work closely with NHS partners to use these capabilities to understand human disease and inform its clinical management. We bring together medical and biological scientists with mathematicians, computer and data scientists to develop and apply methods that exploit these data to their fullest potential.

From analysing patient genomes, to carrying out metagenomic analysis of water samples to using mass spectrometry metabolic profiling techniques, our scientists are studying the unique processes that take place within cells that can lead to disease or poor health outcomes in humans and help track changes in the environment.   

We are using data to answer clinical questions in areas such as cancer, autoimmune and respiratory diseases with the help of clinical colleagues we are translating our findings into novel techniques for clinicians to treat their patients, make predictions about prognosis and drug responsiveness.

Our researchers collaborate with partners at:

People, projects and publications

People

Dr Martin Stolz

Lecturer-Biomedical + Orth. Tribology
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Dr Martin Warner PhD

Associate Professor
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Professor Martyn Hill

Professor of Electromechanical Systems
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Professor Mary Barker PhD, C Psychol

Prof of Psychology & Behavioural Science

Research interests

  • Mary Barker is Professor of Psychology and Behavioural Science. She has a joint appointment in both the Faculty of Medicine and the School of Health Sciences, Faculty of Environmental and Life Sciences, University of Southampton UK.  Mary runs a programme of work in both the UK and in low-income countries aiming to engage young people in improving their sense of agency, well-being and mental health, to benefit their health in general but their diets and physical activity habits more specifically. Her team’s approach is participatory and combines social activism focused on engaging young people in the climate change and health agenda and testing methods of one-to-one support and digital resources including smartphone games. Much of this work takes place as part of her NIHR Programme Grant for Applied Research EACH-B (Engaging Adolescents in Changing Behaviour). She partners in this activity with the TALENT network of colleagues with interests in adolescent health and well-being based in institutions in low-and-middle-income countries. Her team also ran a five-country, longitudinal qualitative study with young people throughout the pandemic exploring their experience, mental health, well-being and resilience, data from which supported UK local and national government COVID messaging to young people. She is adjunct professor at the University of Agder, Norway, and has honorary appointments at the University of Witwatersrand, South Africa, and University College London.
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Professor Matt Ryan

Professor

Research interests

  • Democracy
  • Social Research Methods
  • Web Science

Accepting applications from PhD students

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Dr Matthew Blunt PhD

Associate Professor

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Professor Matthew Garner PhD

Prof Psychology &Affective Neuroscience

Research interests

  • Neuropsychological mechanisms and treatment targets in anxiety disorders. 
  • Psychopharmacology/experimental medicine (acute pharmacological challenge).
  • Psychophysiology (e.g. interoception, autonomic markers of emotion processing),

Accepting applications from PhD students

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Professor Matthew Loxham

Professorial Fellow-Research
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Dr Matthew Rose-Zerilli BSc (Hons), PhD

Lecturer in Integrative Cancer Biology

Research interests

  • Cancer prevention
  • Innate immunity
  • Tumour microenvironment

Accepting applications from PhD students

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Professor Matthew Terry

Professor of Molecular Plant Biology

Research interests

  • Chloroplast development and retrograde signalling to the nucleus
  • Light regulation of wheat growth and development
  • Improving algal photosynthesis

Accepting applications from PhD students

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We are at a very exciting time in Life Science Research. The potential for novel discovery using ‘omics technologies combined with the computer science methodologies is immense.
Professor of Genomics

Related research institutes, centres and groups

Related research institutes, centres and groups

Contact us

Contact us

Contact the Institute for Life Sciences team by emailing: