Enhanced rock weathering and other techniques for removing carbon dioxide from the atmosphere
Novel isotopic signatures of biogeochemical cycling, including iron, chromium, lithium and magnesium, and the response of biogeochemcal cycles to global environmental change
Exploration for new sources of metals and elements critical for emerging green technologies, including lithium and the rare earth elements
In recent years, there have been significant developments in lightwave technologies enabling wide exploitation of optical phase, as exemplified in particular by the dawn of Coherent Optical Communications - the key enabler for the growth in the capacity of the Internet. This is due to many key breakthroughs in laser technology (low-noise low-cost and compact lasers), new revolutionary concepts that have recently been introduced (e.g., the Optical Frequency Comb, the significance of which was demonstrated by the award of a Nobel Prize in 2005), and significant advances in electronics that, thanks to the increased speeds now possible, can accommodate the processing of very complicated coherent (amplitude + phase) signals.
Another exciting field is Hollow Core Optical fibres, which guides ligth in a central hole surrounded by a microstructure that prevents light escaping from the core. Although known for over 20 years, only very recently their fabrication enabled them to use their full potential.
The natural history of asthma and allergy across the lifecourse.Identification of risk factors for asthma and allergy across the lifecourse.Development of risk prediction scores and new diagnostics for asthma.Prevention strategies for asthma and allergy.Phenotyping and endotypic understanding of difficult-to-treat asthma.Understanding the multimorbidity framework of difficult-to-treat asthma.Developing multimodal interventions for difficult-to-treat asthma.
Professor Djukanovic has a lifelong interest in asthma, especially its severe forms. where his focus is on: 1) underlying pathobiological mechanisms of asthma, 2) stratification of asthma into clinical phenotypes and mechanism-based endotypes, 3) unmet needs of severe asthma management. He also has an interest in the mechanisms and treatments of severe viral infections of the lung.
Underlying mechanisms of asthma: Professor Djukanovic has conducted pioneer studies into the pathology of asthma, applying research bronchoscopy (with endobronchial biopsy and bronchoalveolar lavage) and sputum induction. He led the initial task forces which defined the use of these two techniques, thereby paving the way for standardised research approches that enabled in-depth descriptions of the roles of various inflammatory cells and their mediators. He developed an explant model, consisting of bronchial biopsies placed into tissue culture, that could be stimulated ex vivo with relevant triggers, applying as needed, novel agents not yet approved for in vivo use in humans volunteers.
Stratification of asthma into clinical phenotypes and mechanism-based endotypes: Professor Djukanovic led the discovery of biomarkers using omics technology (transcriptomics, proteomics, lipidomics, breathomics). After the first ever study of transcriptomics biomarkers in the epithelium of patients with Chronic Obstructive Pulmonary Disease (COPD), together with a colleague from Amsterdam and two colleagues from Imperial College, London, he created a large (€27 milllion) programme for severe asthma (U-BIOPRED), funded by the EU Innovative Medicines Initiative. This has resulted in more than 100 publications, providing insight into novel phenotypes and endotypes of asthma.
