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Research project

Prof R. Read: MRC Experimental Human Challenge with Genetically Modified Commensals to Investigate Respiratory Tract Mucosal Immunity and Colonisation

Staff

Lead researcher

Professor Robert Read

Chair of Infectious Diseases
Connect with Robert

Email: R.C.Read@soton.ac.uk

Other researchers

Professor Ian Clarke

Professor of Virology

Research interests

  • Transposon mutagenesis of Chlamydia species
  • Cell culture systems and replicons for human noroviruses
Connect with Ian

Email: inc@soton.ac.uk

Professor Saul Faust MBBS, FRCPCH, PhD, FHEA, OBE

Professor Paediatric Immunology & Infect
Connect with Saul

Email: s.faust@soton.ac.uk

Research outputs

Controlled human infection with Neisseria lactamica in late pregnancy to measure horizontal transmission and microbiome changes in mother-neonate pairs
Anastasia A Theodosiou, Jay R Laver, Adam P Dale, David W Cleary, Christine E Jones & Robert C Read, 2022, BMJ Open, 12(5)
DOI: 10.1136/bmjopen-2021-056081
Type: article
Public attitudes to a human challenge study with SARS-CoV-2: a mixed-methods study
Caroline Barker, Katharine Collet, Diane Gbesemete, Maria Piggin, Daniella Watson, Philippa Pristerà, Wendy Lawrence, Emma Smith, Michael Bahrami-Hessari, Halle Johnson, Katherine Baker, Ambar Qavi, Carmel McGrath, Christopher Chiu, Robert C Read & Helen Ward, 2022, Wellcome Open Research , 7, 49
DOI: 10.12688/wellcomeopenres.17516.1
Type: article
Immunogenicity, safety, and reactogenicity of heterologous COVID-19 primary vaccination incorporating mRNA, viral-vector, and protein-adjuvant vaccines in the UK (Com-COV2): a single-blind, randomised, phase 2, non-inferiority trial
Arabella S V Stuart, Robert H Shaw, Xinxue Liu, Melanie Greenland, Parvinder K Aley, Nick J Andrews, J C Cameron, Sue Charlton, Elizabeth A Clutterbuck, Andrea M Collins, Tom Darton, Tanya Dinesh, Christopher J A Duncan, Anna England, Saul N Faust, Daniela M Ferreira, Adam Finn, Anna L Goodman, Christopher A Green, Bassam Hallis, Paul T Heath, Helen Hill, Bryn M Horsington, Teresa Lambe, Rajeka Lazarus, Vincenzo Libri, Patrick J Lillie, Yama F Mujadidi, Ruth Payne, Emma L Plested, Samuel Provstgaard-Morys, Maheshi N Ramasamy, Mary Ramsay, Robert C Read, Hannah Robinson, Gavin R Screaton, Nisha Singh, David P J Turner, Paul J Turner, Iason Vichos, Rachel White, Jonathan S Nguyen-Van-Tam & Matthew D Snape, 2022, The Lancet, 399(10319), 36-49
DOI: 10.1016/S0140-6736(21)02718-5
Type: article
Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial
Alasdair P S Munro, Leila Janani, Victoria Cornelius, Parvinder K Aley, Gavin Babbage, David Baxter, et al., Marcin Bula, Katrina Cathie, Krishna Chatterjee, Kate Dodd, Yvanne Enever, Karishma Gokani, Anna L Goodman, Christopher A Green, Linda Harndahl, John Haughney, Alexander Hicks, Agatha A van der Klaauw, Jonathan Kwok, Teresa Lambe, Vincenzo Libri, Martin J Llewelyn, Alastair C McGregor, Angela M Minassian, Patrick Moore, Mehmood Mughal, Yama F Mujadidi, Jennifer Murira, Orod Osanlou, Rostam Osanlou, Daniel R Owens, Mihaela Pacurar, Adrian Palfreeman, Daniel Pan, Tommy Rampling, Karen Regan, Stephen Saich, Jo Salkeld, Dinesh Saralaya, Sunil Sharma, Ray Sheridan, Ann Sturdy, Emma C Thomson, Shirley Todd, Chris Twelves, Robert C Read, Sue Charlton, Bassam Hallis, Mary Ramsay, Nick J. Andrews, Jonathan Nguyen-Van-Tam, Matthew D. Snape, Xinxue Liu & Saul N Faust, 2021, The Lancet, 398(10318), 2258-2276
DOI: 10.1016/S0140-6736(21)02717-3
Type: article
Antibiotics for lower respiratory tract infection in children presenting in primary care in England (ARTIC PC)
Paul Little, Nick A Francis, Beth Stuart, Gilly O'Reilly, Natalie Thompson, Taeko Becque, Alastair D Hay, Kay Wang, Michael Sharland, Anthony Harnden, Guiqing Yao, James Raftery, Shihua Zhu, Joseph Little, Charlotte Hookham, Kate Rowley, Joanne Euden, Kim Harman, Samuel Coenen, Robert C Read, Catherine Woods, Christopher C Butler, Saul N Faust, Geraldine Leydon, Mandy Wan, Kerenza Hood, Jane Whitehurst, Samantha Richards-Hall, Peter Smith, Michael Thomas, Michael Moore & Theo Verheij, 2021, The Lancet, 398(10309), 1417-1426
DOI: 10.1016/S0140-6736(21)01431-8
Type: article