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Research project

Prof R. Read: A genetically modified nasopharyngeal commensal as a platform for human bacteriotherapy

Staff

Lead researchers

Professor Robert Read

Chair of Infectious Diseases
Connect with Robert

Email: R.C.Read@soton.ac.uk

Other researchers

Professor Ian Clarke

Research interests

  • Transposon mutagenesis of Chlamydia species
  • Cell culture systems and replicons for human noroviruses
Connect with Ian

Email: inc@soton.ac.uk

Professor Saul Faust MBBS, FRCPCH, PhD, FHEA, OBE

Professor Paediatric Immunology & Infect
Connect with Saul

Email: s.faust@soton.ac.uk

Research outputs

Safety and immunogenicity of heterologous versus homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine (Com-COV): a single-blind, randomised, non-inferiority trial
Xinxue Liu, Robert H. Shaw, Arabella S.V. Stuart, Melanie Greenland, Parvinder K. Aley, Nick J. Andrews, J. Claire Cameron, Sue Charlton, Elizabeth A. Clutterbuck, Andrea M. Collins, Tanya Dinesh, Anna England, Saul N. Faust, Daniela M. Ferreira, Adam Finn, Christopher A. Green, Bassam Hallis, Paul T. Heath, Helen Hill, Teresa Lambe, Rajeka Lazarus, Vincenzo Libri, Fei Long, Yama F. Mujadidi, Emma L. Plested, Samuel Provstgaard-Morys, Maheshi N. Ramasamy, Mary Ramsay, Robert C. Read, Hannah Robinson, Nisha Singh, David P.J. Turner, Paul J. Turner, Laura L. Walker, Rachel White, Jonathan S. Nguyen-Van-Tam, Matthew D. Snape, Alasdair P.S. Munro, Jazz Bartholomew, Laura Presland, Sarah Horswill, Sarah Warren, Sophie Varkonyi-Clifford, Stephen Saich, Kirsty Adams, Marivic Ricamara, Nicola Turner, Nicole Y. Yee Ting, Sarah Whittley & Hannah Sainsbury, 2021, The Lancet, 398(10303), 856-869
DOI: 10.1016/S0140-6736(21)01694-9
Type: article
A recombinant commensal bacteria elicits heterologous antigen-specific immune responses during pharyngeal carriage
Jay R Laver, Diane Gbesemete, Adam P Dale, Zoe C Pounce, Carl N Webb, Eleanor F Roche, Graham Berreen, Konstantinos Belogiannis, Alison R Hill, Muktar M Ibrahim, David W Cleary, Anish K Pandey, Holly E Humphries, Lauren Allen, Hans de Graaf, Martin C Maiden, Saul N Faust, Andrew R Gorringe & Robert C Read, 2021, Science Translational Medicine, 13(601)
DOI: 10.1126/scitranslmed.abe8573
Type: article
The infant pharyngeal microbiomes: origin, impact and manipulation
Christine E Jones, Robert Read & Anastasia Theodosiou, 2020, Current Opinion in Infectious Diseases, 33(6), 548-555
DOI: 10.1097/QCO.0000000000000691
Type: article
ACCORD
Tom Wilkinson, Rupert Dixon, Clive Page, Miles Carroll, Gareth Griffiths, Ling-Pei Ho, Anthony De Soyza, Timothy Felton, Keir E Lewis, Karen Phekoo, James D Chalmers, Anthony Gordon, Lorcan McGarvey, Jillian Doherty, Robert C Read, Manu Shankar-Hari, Nuria Martinez-Alier, Michael O'Kelly, Graeme Duncan, Roelize Walles, James Sykes, Charlotte Summers & Dave Singh, 2020, Trials, 21, 691
DOI: 10.1186/s13063-020-04584-9
Type: article
Controlled human infection with Bordetella pertussis induces asymptomatic, immunising colonisation
Hans de Graaf, Muktar Ibrahim, Alison R Hill, Diane Gbesemete, Andrew T Vaughan, Andrew Gorringe, Andrew Preston, Annemaire M Buisman, Saul Faust, Kent E. Kester, Guy Berbers, Dimitri A. Diavatopoulos & Robert Read, 2020, Clinical Infectious Diseases, 71(2), 403-411
DOI: 10.1093/cid/ciz840
Type: article