Project overview
We propose that miRNAs play a critical role in the regulation of skeletal stem cell fate and function. We will determine the role of miRNAs in the maintenance of stem phenotype or enhancement of bone stem cell differentiation and mechanisms involved including cytoskeletal or epigenetic changes. We have recently shown that defined nanotopographies are capable of robustly regulating SSC fate in the absence of chemical cues. We will therefore use custom designed nanotopographies to control SSC phenotype (for instance, to induce osteogenesis or maintain SSC numbers) and examine how miRNAs affect stem cell responses through modulation of epigenetic, biochemical and biomechanical processes. This study will facilitate our understanding of the mechanisms involved in the regulation of skeletal stem cell fate and function.
Staff
Lead researchers
Research outputs
Joanna Greenhough, Manos Papadakis, Ramsey Cutress, Paul Townsend, Richard Oreffo & Rahul Tare,
2016, Scientific Reports, 6, 1-15
DOI: 10.1038/srep33504
Type: article
Catarina Costa Moura, Rahul Tare, Richard O.C. Oreffo & Sumeet Mahajan,
2016, Journal of the Royal Society Interface, 13(118), 1-12
Type: article
Daniel Tang, Rahul S. Tare, Liang-Yo Yang, David F. Williams, Keng-Liang Ou & Richard Oreffo,
2016, Biomaterials, 83, 363-382
Type: article
Richard Oreffo, M. Megges & J. Adjaye,
2015, Stem Cell Research, 16(1), 128-132
Type: article
Justyna P. Smus, Catarina Costa Moura, Emma McMorrow, Rahul S. Tare, Richard O.C. Oreffo & Sumeet Mahajan,
2015, Chemical Science, 6(12), 7089-7096
DOI: 10.1039/C5SC02168E
Type: article