Project overview
We propose that miRNAs play a critical role in the regulation of skeletal stem cell fate and function. We will determine the role of miRNAs in the maintenance of stem phenotype or enhancement of bone stem cell differentiation and mechanisms involved including cytoskeletal or epigenetic changes. We have recently shown that defined nanotopographies are capable of robustly regulating SSC fate in the absence of chemical cues. We will therefore use custom designed nanotopographies to control SSC phenotype (for instance, to induce osteogenesis or maintain SSC numbers) and examine how miRNAs affect stem cell responses through modulation of epigenetic, biochemical and biomechanical processes. This study will facilitate our understanding of the mechanisms involved in the regulation of skeletal stem cell fate and function.
Research outputs
Gianluca Cidonio, Michael Glinka, Yang-Hee Kim, Jonathan I. Dawson & Richard O. C. Oreffo,
2021
Type: bookChapter
Janos M. Kanczler, Julia A. Wells & Richard O. C. Oreffo,
2020
Type: bookChapter
Richard Oreffo, Andrew Greer, Vitali Goriainov, Janos Kanczler, Cameron Russell Macgregor Black, Lesley Turner, R. Meek, Karl Burgess, Ian MacLaren, Matthew J. Dalby & Nikolaj Gadegaard,
2020, ACS Applied Materials and Interfaces, 12(30), 33541-33549
Type: article
C. Black, J.M. Kanczler, M. C. de Andres, L.J. White, F.M. Savi, O. Bas, S. Saifzadeh, J. Henkel, A. Zannettino, S. Gronthos, M.A. Woodruff, D.W. Hutmacher & R.O.C. Oreffo,
2020, Biomaterials, 247
Type: article
Patricia Goggin, Elaine, Ming Li Ho, Helmut Gnaegi, Stuart Searle, Richard Oreffo & Philipp Schneider,
2020, Bone, 131
Type: review