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Research project

MacArthur BB/L000512/1 Dissecting the molecular basis of cell-cell variability in mouse embryonic stem cell populations using system approaches

Staff

Lead researcher

Professor Benjamin Macarthur

Personal Chair

Research interests

  • Mathematical modeling
  • Machine learning 
  • Networks
Connect with Benjamin

Email: bdm@soton.ac.uk

Research outputs

Machine learning of stem cell identities from single-cell expression data via regulatory network archetypes
Patrick Stumpf & Benjamin Macarthur, 2019, Frontiers in Genetics, 10
DOI: 10.3389/fgene.2019.00002
Type: article
Noise-processing by signaling networks
Styliani Kontogeorgaki, Ruben Sanchez Garcia, Robert Ewing, Konstantinos Zygalakis & Benjamin Macarthur, 2017, Scientific Reports, 7(1)
DOI: 10.1038/s41598-017-00659-x
Type: article
Stem cell differentiation as a non-Markov stochastic process
Patrick Stumpf, Rosanna C.G. Smith, Michael Lenz, Andreas, A. Schuppert, Franz-Josef Muller, Ann Babtie, Thalia E. Chan, Michael P.H. Stumpf, Colin P. Please, Sam D. Howison, Fumio Arai & Benjamin D. Macarthur, 2017, Cell Systems, 5(3), 268-282.e7
DOI: 10.1016/j.cels.2017.08.009
Type: article
Information-theoretic approaches to understanding stem cell variability
Rosanna Smith & Benjamin Macarthur, 2017, Current Stem Cell Reports, 3(3), 225-231
DOI: 10.1007/s40778-017-0093-5
Type: article
Nanog fluctuations in embryonic stem cells highlight the problem of measurement in cell biology
Rosanna Smith, Patrick Stumpf, Sonya Ridden, Aaron Sim, Sarah Filippi, Heather Harrington & Benjamin Macarthur, 2017, Biophysical Journal, 112(12), 2641–2652
DOI: 10.1016/j.bpj.2017.05.005
Type: article