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Research project

J Nicoll art/pg2006/4

Staff

Lead researchers

Professor James Nicoll

Connect with James

Email: J.Nicoll@soton.ac.uk

Other researchers

Professor Delphine Boche

Professor of Neuroimmunopathology

Research interests

  • Neuroimmunology and neurodegeneration
  • Immunophenotyping immune cells
  • Human brain pathology
Connect with Delphine

Email: D.Boche@soton.ac.uk

Emeritus Professor Clive Holmes

Connect with Clive

Email: C.Holmes@soton.ac.uk

Research outputs

No replicating evidence for anti-amyloid-β autoantibodies in cerebral amyloid angiopathy-related inflammation
Emma van den Berg, Rian Roelofs, Lieke Jakel, Steven M. Greenberg, Andreas Charidimou, Ellis S. van Etten, Delphine Boche, Catharina J.M. Klijn, Floris H.B.M. Schreuder, Bea Kuiperij & Marcel Verbeek, 2024, Annals of Clinical and Translational Neurology
Type: article
Histopathological correlates of hemorrhagic lesions on ex vivo MRI in immunized Alzheimer’s disease cases.
Ashley Scherlek, Mariel Kozberg, James Nicoll, Valentina Perosa, Whitney Freeze, Louise van der Weerd, Brian Bacskai, Steven Greenberg, Matthew Frosch, Delphine Boche & Susanne van Veluw, 2022, Brain Communications
Type: article
Understanding cause and effect in Alzheimer's pathophysiology: implications for clinical trials
Delphine Boche & James Nicoll, 2020, Neuropathology and Applied Neurobiology
Type: review
Microglial motility in Alzheimer’s disease and after Aβ42 immunotherapy: a human post-mortem study
Diana, Karina Franco Bocanegra, Bethany George, Laurie C. Lau, Clive Holmes, James A.R. Nicoll & Delphine Boche, 2019, Acta Neuropathologica Communications, 7(1), 174
DOI: 10.1186/s40478-019-0828-x
Type: article
Persistent neuropathological effects 14 years following amyloid-β immunisation in Alzheimer’s disease
James A.R. Nicoll, George R. Buckland, Charlotte H. Harrison, Anton Page, Scott Harris, Seth Love, James W. Neal, Clive Holmes & Delphine Boche, 2019, Brain, 142(7), 2113-2126
DOI: 10.1093/brain/awz142
Type: article