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Research project

Hanson RG/15/17/31749 Epigenetic Biomarkers and Determinants of Cardiovascular Risk in Children

Staff

Lead researcher

Emeritus Professor Mark Hanson

Connect with Mark

Email: M.Hanson@soton.ac.uk

Other researchers

Professor Cyrus Cooper

Prof Rheumatology Clinical Epidemiology

Research interests

  • Key research contributions have been:
  • discovery of the developmental influences which contribute to the risk of osteoporosis and hip fracture in late adulthood
  • demonstration that maternal vitamin D insufficiency is associated with sub-optimal bone mineral accrual in childhood
Connect with Cyrus

Email: cc@mrc.soton.ac.uk

Professor Keith Godfrey

Associate Dean Enterprise
Connect with Keith

Email: kmg@mrc.soton.ac.uk

Professor Karen Lillycrop

Professor of Epigenetics

Research interests

  • Epigenetics
  • Human Disease
Connect with Karen

Email: K.A.Lillycrop@soton.ac.uk

Emeritus Professor Hazel Inskip MSc, PhD, FFPH

Connect with Hazel

Email: hmi@mrc.soton.ac.uk

Collaborating research institutes, centres and groups

Plants and Food Security

We study the response of plants to the environment at the molecular, whole plant and ecological levels. This includes interactions with nematodes, insects and microbes.

Research outputs

The inheritance of cardiovascular disease risk
Mark Hanson, 2019, Acta Paediatrica, 108(10), 1747-1756
DOI: 10.1111/apa.14813
Type: article
Association of birth weight with type 2 diabetes and glycemic traits: A Mendelian randomization study
Sarah Crozier, Keith Godfrey, Cyrus Cooper, Karen Jameson, Hazel Inskip & Elaine Dennison, 2019, JAMA Network Open, 2(9)
DOI: 10.1001/jamanetworkopen.2019.10915
Type: article
In epigenetic studies including cell type adjustments in regression models can introduce multicollinearity, resulting in apparent reversal of direction of association
Sheila Barton, Phillip E. Melton, Philip Titcombe, Robert Murray, Sebastian Rauschert, Karen Lillycrop, Rae-Chi Huang, Joanna D. Holbrook & Keith Godfrey, 2019, Frontiers in Genetics, 10
DOI: 10.3389/fgene.2019.00816
Type: article
Maternal smoking during pregnancy induces persistent epigenetic changes into adolescence, independent of postnatal smoke exposure and is associated with cardiometabolic risk
Sebastian Rauschert, Phillip Melton, Graham Burdge, Jeffrey Craig, Keith Godfrey, Joanna D Holbrook, Karen Lillycrop, Trevor Mori, Lawrence J Beilin, Wendy H. Oddy, Craig Pennell & Rae-Chi Huang, 2019, Frontiers in Genetics, 10, 1-15
DOI: 10.3389/fgene.2019.00770
Type: article
Determinants of Intramyocellular lipid accumulation in early childhood
Navin Michael, Varsha Gupta, Suresh Anand Sadananthan, Aparna Sampathkumar, Li Chen, Hong Pan, Mya Thway Tint, Kuan Jin Lee, See Ling Loy, Izzuddin M. Aris, Lynette Pei-Chi Shek , Fabian Yap, Keith Godfrey, Melvin Khee-Shing Leow, Yung Seng Lee, Michael S. Kramer, Christiani Jevakumar Henry, Marielle V. Fortier, Yap Seng Chong, Peter D. Gluckman, Neerja Karnani & Sendhil Velan, 2019, International Journal of Obesity
DOI: 10.1038/s41366-019-0435-8
Type: article