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Research project

(Fellowship) Investigating the trigger for fibroblast senescence in colorectal cancer: a novel

Staff

Lead researchers

Dr Rahul Bhome

Connect with Rahul

Email: R.Bhome@soton.ac.uk

Other researchers

Professor Alex Mirnezami

Professor of Surgical Oncology
Connect with Alex

Email: A.H.Mirnezami@soton.ac.uk

Dr Emre Sayan

Associate Professor

Research interests

  • - The link between EMT and apoptosis/therapy resistance.
  • - Mechanobiology of EMT: How tumour stiffness associates with EMT and creates tumour microenvironment.
  • - How EMT influences non-cancer cells in tumour microenvironment (e.g. T cell recruitment or fibroblast-myofibroblast differentiation).
Connect with Emre

Email: A.E.Sayan@soton.ac.uk

Research outputs

The colorectal cancer microenvironment
Rahul Bhome, Massimiliano Mellone, Katherine Emo, Gareth J. Thomas, A. Emre Sayan & Alex H. Mirnezami, 2018
DOI: 10.1007/978-1-4939-7765-9_6
Type: bookChapter
Exosomal microRNAs derived from colorectal cancer-associated fibroblasts:
Rahul Bhome, Rebecca W. Goh, Marc D. Bullock, Nir Pillar, Stephen M. Thirdborough, Massimiliano Mellone, Reza Mirnezami, Dieter Galea, Kirill Veselkov, Quan Gu, Timothy J. Underwood, John N. Primrose, Olivier De Wever, Noam Shomron, A. Emre Sayan & Alex H. Mirnezami, 2017, Aging, 9(12), 2666-2694
DOI: 10.18632/aging.101355
Type: article
Profiling the microRNA payload of exosomes derived from ex vivo primary colorectal fibroblasts
Rahul Bhome, Rebecca Goh, Karen Pickard, Massimiliano Mellone, A. Emre Sayan & Alex Mirnezami, 2017
DOI: 10.1007/978-1-4939-6524-3_11
Type: bookChapter