Dr H M Haitchi ADAM33 gene and environmental interactions in developing lungs and their involvement in the early life origin of asthma

Staff

Lead researcher

Dr Hans Michael Haitchi MD, MMed(INT), PhD, PD, MRCP(London), FHEA, PGcert

Associate Professor

Research interests

Study of the asthma susceptibility gene A Disintegrin and Metalloprotease 33 (ADAM33) in early life and adult asthma and other chronic lung diseases.
Development of novel Anti-ADAM33 agents as potential disease modifying asthma therapy.
Multiomic study of the influence of the maternal environment (e.g. allergic asthma, obesity) during pregnancy on ADAM33 and other mediators and the early origin of lung disease in the Maternal Environment in Pregnancy (MEP) cohort.

Connect with Hans Michael

Email: H.M.Haitchi@soton.ac.uk

Research outputs

Towards an artificial human lung

Maria Victoria Humbert, Cosma Mirella Spalluto, Joseph Bell, Cornelia Blume, Franco Conforti, Elizabeth R Davies, Lareb S N Dean, Paul Elkington, Hans Michael Haitchi, Claire Jackson, Mark G Jones, Matthew Loxham, Jane S Lucas, Hywel Morgan, Marta Polak, Karl J Staples, Emily J Swindle, Liku Tezera, Alastair Watson & Tom M A Wilkinson, 2022, The European respiratory journal, 60(6)

DOI: 10.1183/13993003.00455-2022

Type: article

Multimorbidity in difficult asthma: the need for personalised and non-pharmacological approaches to address a difficult breathing syndrome

Hans Michael Haitchi, Judit Varkonyi-Sepp, Anna Freeman & Ben Ainsworth, 2022, Journal of Personalized Medicine, 12(9)

DOI: 10.3390/jpm12091435

Type: article

The effect of the COVID-19 pandemic on severe asthma care in Europe

Katrien Eger, Dora Paroczai, Alison Bacon, Florence Schleich, Svetlana Sergejeva, Arnaud Bourdin, Isabelle Vachier, Eleftherios Zervas, Konstantinos Katsoulis, Dimosthenis Papapetrou, Konstantinos Kostikas, Zsuzsanna Csoma, Enrico Heffler, Giorgio Walter Canonica, Ineta Grisle, Kristina Bieksiene, Jolita Palacionyte, Anneke Ten Brinke, Simone Hashimoto, Frank W.j.m. Smeenk, Gert-jan Braunstahl, Simone Van Der Sar, Florin Mihălţan, Natalia Nenasheva, Marina Peredelskaya, Biljana Zvezdin, Ivan Čekerevac, Sanja Hromiš, Vojislav Ćupurdija, Zorica Lazic, Branislava Milenkovic, Sanja Dimic-janjic, Valentyna Yasinska, Barbro Dahlén, Apostolos Bossios, Nikolaos Lazarinis, David Aronsson, Arne Egesten, Abul Kashem Mohammad Munir, Lars Ahlbeck, Christer Janson, Sabina Škrgat, Natalija Edelbaher, Joerg Leuppi, Fabienne Jaun, Jochen Rüdiger, Nikolay Pavlov, Pietro Gianella, Reta Fischer, Florian Charbonnier, Rekha Chaudhuri, Steven James Smith, Simon Doe, Michelle Fawdon, Matthew Masoli, Liam Heaney, Hans Michael Haitchi, Ramesh Kurukulaaratchy, Olivia Fulton, Betty Frankemölle, Toni Gibson, Karen Needham, Peter Howarth, Ratko Djukanovic, Elisabeth Bel & Michael Hyland, 2022, ERJ Open Research, 8(2)

DOI: 10.1183/23120541.00065-2022

Type: article

The detrimental clinical associations of anxiety and depression with difficult asthma outcomes

Wei Chern Gavin Fong, Ishmail Rafiq, Matthew Harvey, Sabina Stanescu, Ben Ainsworth, Judit Varkonyi-Sepp, Heena Mistry, Mohammed Aref Kyyaly, Clair Barber, Anna Freeman, Tom Wilkinson, Ratko Djukanovic, Paddy Dennison, Hans Michael Haitchi & Ramesh J Kurukulaaratchy, 2022, Journal of Personalized Medicine, 12(5)

DOI: 10.3390/jpm12050686

Type: article

Validation and further insight into the International Severe Asthma Registry (ISAR) eosinophil gradient algorithm in the Wessex AsThma CoHort of difficult asthma (WATCH) using historical blood eosinophil counts and induced sputum

Clair Barber, Adnan Azim, Colin Newell, Aref Kyyaly, Hitasha Rupani, Hans Michael Haitchi, Peter Howarth & Ramesh Kurukulaaratchy, 2022, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 52(6), 792-796

DOI: 10.1111/cea.14109

Type: letterEditorial