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Research project

Computational modelling to evaluate, understand and predict the placental transfer of xenobiotics as an integrated system

Staff

Lead researchers

Dr Bram Sengers

Associate Professor
Connect with Bram

Email: B.G.Sengers@soton.ac.uk

Other researchers

Professor Xunli Zhang PhD, DIC, FRSC, CChem, CEng

Professor of Bioengineering

Research interests

  • Microfluidics and Lab-on-a-Chip Technologies
  • Biomedical and Chemical Engineering
  • Nanomaterials
Connect with Xunli

Email: XL.Zhang@soton.ac.uk

Professor Rohan Lewis PhD, FTPS

Prof of Placental&Integrative Physiology
Connect with Rohan

Email: Rohan.Lewis@soton.ac.uk

Dr Jane Cleal PhD

Associate Professor

Research interests

  • Areas of Scientific Expertise:
  • Reproductive Cell Biology – Fundamental mechanisms of cell biology in placenta and endometrium and the impact on the intra-uterine environment, fetal development and lifelong health.Regulation of Reproductive Cell Biology – Maternal exposures and molecular regulation of cellular gene expression, phenotype and function in placenta and endometrium and the clinical translation.Disease/phenotype – Fetal growth, Obesity, Cardiometabolic programming, Subfertility, Recurrent pregnancy loss.Cellular mechanisms – Membrane transport, endocytosis, vesicular transport & signalling, gene transcription, microRNA biology, epigenetic regulation.Vitamin D - Transport, regulation, metabolism and signalling.
Connect with Jane

Email: J.K.CLEAL@soton.ac.uk

Research outputs

Computational modelling of paracellular diffusion and OCT3 mediated transport of metformin in the perfused human placenta
Emma M. Lofthouse, Jane Cleal, Rohan M. Lewis & Bram G. Sengers, 2023, Journal of Pharmaceutical Sciences, 112(9), 2570-2580
DOI: 10.1016/j.xphs.2023.05.008
Type: article
3D Visualisation of trans-syncytial nanopores provides a pathway for paracellular diffusion across the human placental syncytiotrophoblast
Rohan Lewis, Harikesan Baskaran, Jools Green, Stanimir A. Tashev, Eleni Palaiologou, Emma Lofthouse, Jane Cleal, Anthony Page, David Chatelet, Patricia Goggin & Bram Sengers, 2022, iScience, 25(12)
DOI: 10.1101/2022.01.26.477815
Type: article
Modelling of 3D placental cell features using deep learning
Benjamin Mills, James Grant-Jacob, Benita, Scout MacKay, Rohan Lewis & Bram Sengers, 2022
Type: conference
Endocytosis in the placenta
Laura D F Cooke, David A Tumbarello, Nicholas C Harvey, Jaswinder K Sethi, Rohan M Lewis & Jane K Cleal, 2021, Placenta, 113, 67-73
DOI: 10.1016/j.placenta.2021.04.014
Type: review
Glibenclamide transfer across the perfused human placenta is determined by albumin binding not transporter activity
Emma Lofthouse, Jane Cleal, Georgina J Hudson, Rohan Lewis & Bram Sengers, 2020, European Journal of Pharmaceutical Sciences, 152
DOI: 10.1016/j.ejps.2020.105436
Type: article