Research project

Bioengineering to combat the tuberculosis pandemic

Lead researchers:

Professor Paul Elkington
Other researchers:

Professor Xunli Zhang
Research funder:

Medical Research Council
Status:

Not active

Project overview

We will combine engineering and biological approaches to investigate the host-pathogen interaction and identify new therapeutic targets.

Staff

Lead researchers

Professor Paul Elkington

Director of Inst. for Medical Innovation

Research interests

tuberculosis
immunopathology
diagnosis

Connect with Paul

Email: P.Elkington@soton.ac.uk

Other researchers

Professor Xunli Zhang PhD, DIC, FRSC, CChem, CEng

Professor of Bioengineering

Research interests

Microfluidics and Lab-on-a-Chip Technologies
Biomedical and Chemical Engineering
Nanomaterials

Connect with Xunli

Email: XL.Zhang@soton.ac.uk

Research outputs

Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α

Liku B. Tezera, Magdalena K Bielecka, Paul Ogongo, Naomi F. Walker, Matthew Ellis, Diana J. Garay-Baquero, Kristian Thomas, Michaela T. Reichmann, David A. Johnston, Katalin Andrea Wilkinson, Mohamed Ahmed, Sanjay Jogai, Suwan N. Jayasinghe, Robert J. Wilkinson, Salah Mansour, Gareth J. Thomas, Christian H. Ottensmeier, Alasdair Leslie & Paul T. Elkington, 2020, eLife, 9

DOI: 10.7554/eLife.52668

Type: article

Reconsidering the optimal immune response to Mycobacterium tuberculosis

Liku Bekele Tezera, Salah Mansour & Paul Elkington, 2019, American Journal of Respiratory and Critical Care Medicine, 201(4)

DOI: 10.1164/rccm.201908-1506PP

Type: review

In vitro granuloma models of tuberculosis

Paul Elkington, Maria Lerm, Nidhi Kapoor, Robert Mahon, Elsje Pienaar, Dongeun Huh, Deepak Kaushal & Larry Schlesinger, 2019, Journal of Infectious Diseases, 219(12), 1858–1866

DOI: 10.1093/infdis/jiz020

Type: review

Implications of tuberculosis reactivation after immune checkpoint inhibition

Paul Elkington, Adrian Bateman, Gareth Thomas & Christian Ottensmeier, 2018, American Journal of Respiratory and Critical Care Medicine, 198(11), 1451-1453

DOI: 10.1164/rccm.201807-1250LE

Type: letterEditorial

Advanced cellular systems to study tuberculosis treatment

Magdalena K. Bielecka & Paul Elkington, 2018, Current Opinion in Pharmacology, 42, 16-21

DOI: 10.1016/j.coph.2018.06.005

Type: article