Bioengineering to combat the tuberculosis pandemic

Project overview

We will combine engineering and biological approaches to investigate the host-pathogen interaction and identify new therapeutic targets.

Staff

Lead researcher

Professor Paul Elkington

Director of Inst. for Medical Innovation

Research interests

tuberculosis
immunopathology
diagnosis

Connect with Paul

Email: P.Elkington@soton.ac.uk

Other researchers

Professor Xunli Zhang PhD, DIC, FRSC, CChem, CEng

Head of Department-Chemical Engineerg

Research interests

Xunli’s key expertise lies in the area of microfluidics technology from design and fabrication of microfluidic devices, through the development of in-situ monitoring methods for bio/chemical processes, to microfluidic modelling, microsystems integration and automation. The application is largely associated with biomedical challenges like patient specific design of microfluidic devices for cancer treatment, rapid diagnosis, and tackling antimicrobial resistance (AMR). The continuous flow reactors have been used for the synthesis of a range of nanoparticles, both organic and inorganic, for application in drug delivery and energy saving. The technologies developed in his research have also found great potential for industrial applications through a variety of industrial collaborations.

Connect with Xunli

Email: XL.Zhang@soton.ac.uk

Research outputs

Infections due to Dysregulated Immunity: An emerging complication of Cancer Immunotherapy

Tommaso Morelli, Kohei Fujita, Gil Redelman-Sidi & Paul Elkington, 2021, Thorax

DOI: 10.1136/thoraxjnl-2021-217260

Type: article

Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets

Michaela T. Reichmann, Liku Bekele Tezera, Andres Vallejo Pulido, Milica Vukmirovic, Rui Xiao, James Reynolds, Sanjay Jogai, Susan Wilson, Benjamin Marshall, Mark Jones, Alasdair Leslie, Jeanine M. D'Armiento, Naftali Kaminski, Marta Polak & Paul Elkington, 2021, Journal of Clinical Investigation, 131(15), 1-16

DOI: 10.1172/JCI148136

Type: article

Doxycycline host-directed therapy in human pulmonary tuberculosis

Quig Miow, Andres Vallejo Pulido, Yu Wang, Jia Hong, Chen Bai, Felicia Teo, Alvin Wang, Hong Loh, Tuan Tan, Ying Ding, Hoi She, Suay Gan, Nicholas Paton, Josephine Lum, Alicia Tay, Cynthia Chee, Paul Tambyah, Marta Polak, Yee Wang, Amit Singhal, Paul Elkington, Jon S. Friedland & Catherine W.M. Ong, 2021, Journal of Clinical Investigation, 131(15)

DOI: 10.1172/JCI141895

Type: article

A Personal respirator to improve protection for healthcare workers treating COVID-19 (PeRSo)

Paul Elkington, Alexander Dickinson, Mark Mavrogordato, Daniel Spencer, Richard Gillams, Antonio De Grazia, Sebastian Rosini, Diana Garay Baquero, Laura Diment, Nitin Mahobia, Alexandra Mant, Tom Baynham & Hywel Morgan, 2021, Frontiers in Medical Technology, 3(664259), 1-11

DOI: 10.3389/fmedt.2021.664259

Type: article

Comprehensive plasma proteomic profiling reveals biomarkers for active tuberculosis

Diana J. Garay-Baquero, Cory H. White, Naomi F. Walker, Marc Tebruegge, Hannah F. Schiff, Cesar Ugarte-Gil, Stephen Morris-Jones, Ben G. Marshall, Antigoni Manousopoulou, John Adamson, Andres F. Vallejo, Magdalena K. Bielecka, Robert J. Wilkinson, Liku B. Tezera, Christopher H. Woelk, Spiros D. Garbis & Paul Elkington, 2020, JCI Insight, 5(18)

DOI: 10.1172/jci.insight.137427

Type: article