Research
Research groups
Research interests
- Infrared (IR) Spectroscopy / Raman Spectroscopy
- Respiratory Distress Syndrome (RDS)
- Particles in Exhaled Air (PExA)
Current research
Hings Luo's research explores an “omics” approach to oxygen-induced alveolar damage with a comprehensive quantification of alveolar and serological markers of redox signalling, oxidative stress, lung surfactant lipidomic and proteomics candidates that govern the heterogeneous nature and endotypes of hypoxic/hyperoxic organ injury. Better understanding of metabolic signatures may enable further improvements in diagnosis and management of hypoxia/hyperoxia mediated organ damage. However, laboratory analysis often takes too long to inform critical clinical decisions. Real-time optical spectroscopic measurements in combination with machine learning have the potential to enable rapid bedside analysis of multi-model metabolomic data within few minutes without sample preparation and basic prototypes are already under development for neonatal Respiratory Distress Syndrome (nRDS) application. The ultimate vision of this project is to develop benchtop analytical platforms exploiting disposable spectroscopic chips (developed in the cleanroom) that can be deployed to guide individualised therapy in critically ill patients in an intensive care unit (ICU) setting. This multidisciplinary project is being undertaken collaboratively between Optoelectronics Research Centre and Biomedical Research Centre at the University of Southampton/University Hospital Southampton.