About the project
In this project you will use organic chemistry to synthesise and evaluate a new class of nucleic acids designed to deliver rapid and simple detection and diagnostic approaches.
Sensing and detection are crucial aspects of defence and security. Rapid and robust detection of chemical and biological warfare agents is essential for immediate risk assessment, mitigation, and decision-making in the field. Similarly, point-of-care diagnostics enable accurate and rapid disease diagnosis and allow effective therapeutic intervention and epidemiological surveillance; the recent COVID-19 pandemic has highlighted the importance of fast and decentralised testing. Although detection systems based on nucleic acids are among the most sensitive and specific, these assays involve trade-offs between sensitivity, specificity, simplicity, cost, and speed.
This project will combine state of the art nucleic acid chemistry, photochemistry and electrochemistry with exciting emerging diagnostic CRISPR/Cas technologies. You will start by synthesising and characterising the modified nucleic acids. You will then develop proof-of-principle detection systems using the technology, one focused on detecting biological agents and the other focused on the detection of chemical agents.
You will gain experience in organic synthesis, nucleic acid chemistry, and senor development.
The Centre for Doctoral Training in Complex Integrated Systems for Defence & Security (CISDnS) is committed to promoting equality, diversity and inclusivity. We welcome all applicants regardless of their gender, ethnicity, disability, sexual orientation or age, and will give full consideration to applicants seeking flexible working patterns and those who have taken a career break or are transitioning into a new role. The University has a generous maternity policy, onsite childcare facilities, and offers a range of benefits to help ensure employees’ well-being and work-life balance.
