Research project

S Khakoo: Using MHC Class l Peptides to modulate NK cell activity, as a basis for immunotherapy

Lead researchers:

Professor Salim Khakoo
Research funder:

Medical Research Council
Status:

Not active

Staff

Lead researchers

Professor Salim Khakoo

Professor of Hepatology

Connect with Salim

Email: S.I.Khakoo@soton.ac.uk

Research outputs

Disruption of the NKG2A:HLA-E immune checkpoint axis to enhance NK cell activation against Cancer

Jack G. Fisher, Amber D. P. Doyle, Lara V. Graham, Salim I. Khakoo & Matthew D. Blunt, 2022, Vaccines, 10(12)

DOI: 10.3390/vaccines10121993

Type: article

Anti-viral responses of tissue-resident CD49a+ lung NK cells are dysregulated in COPD

Grace Elizabeth Cooper, Jemma Mayall, Chantal Donovan, Tatt J. Haw, Kurtis F. Budden, Nicole G. Hansbro, Evy E. Blomme, Tania Maes, Chia Wei Kong, Jay C. Horvat, Salim I. Khakoo, Tom MA Wilkinson, Philip M. Hansbro & Karl J. Staples, 2022, American Journal of Respiratory and Critical Care Medicine

DOI: 10.1164/rccm.202205-0848OC

Type: article

KIR2DS2 expression identifies NK cells with enhanced anticancer activity

Matthew Blunt, Mark Cragg, Amber Doyle, Jack, Graham Fisher, Salim Khakoo, Francesco Forconi, Peter Johnson, Marta Ewa Polak, Lara, Victoria Graham, Andres Vallejo Pulido, Rebecca Fulton & Matthew Carter, 2022, The Journal of Immunology, 209 (2)(2), 379-390

DOI: 10.4049/jimmunol.2101139

Type: article

Selinexor enhances NK cell activation against malignant B cells via downregulation of HLA-E

Jack, Graham Fisher, Salim Khakoo, Mark Cragg, Francesco Forconi, Peter Johnson, Amber Doyle, christopher Walker, yosef landesman & Matthew Blunt, 2021, Frontiers in Oncology

DOI: 10.3389/fonc.2021.785635

Type: article

The role of NK cells in oncolytic viral therapy

Frazer Warricker, Salim I. Khakoo & Matthew D. Blunt, 2021, Journal of Translational Genetics and Genomics, 5, 304-322

DOI: 10.20517/jtgg.2021.27

Type: article