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Research project

Prof Tom Fleming BBSRC Pre-implantation Embryos

Staff

Lead researchers

Emeritus Professor Thomas Fleming

Connect with Thomas

Email: T.P.Fleming@soton.ac.uk

Other researchers

Emeritus Professor Mark Hanson

Connect with Mark

Email: M.Hanson@soton.ac.uk

Professor Rohan Lewis PhD, FTPS

Prof of Placental&Integrative Physiology
Connect with Rohan

Email: Rohan.Lewis@soton.ac.uk

Research outputs

Mouse maternal protein restriction during preimplantation alone permanently alters brain neuron proportion and adult short-term memory
Joanna, Mary Gould, Phoebe J. Smith, Chris J. Airey, Emily J. Mort, Lauren E Airey, Frazer DM Warricker, Jennifer, Elizabeth Pearson-Farr, Eleanor C Weston, Philippa JW Gould, Oliver G Semmence, Katie L. Restall, J.A Watts, Patrick C McHugh, Stephanie J Smith, Jennifer M. Dewing, Thomas P. Fleming & Sandrine Willaime-Morawek, 2018, Proceedings of National Academy of Sciences of the United States of America, 115(13), E7398-E7407
DOI: 10.1073/pnas.1721876115
Type: article
Origins of lifetime health around the time of conception
T.P. Fleming, A. Watkins, M.A. Velazquez, J. C. Mathers, A.M. Prentice, J. Stephenson, Mary Barker, R. Saffery, Chittaranjan S. Yajnik, Judith Eckert, Mark Hanson, T. Forrester, Peter D. Gluckman & Keith Godfrey, 2018, The Lancet, 391(10132), 1842–1852
DOI: 10.1016/S0140-6736(18)30312-X
Type: article
Insulin and branched-chain amino acid depletion during mouse preimplantation embryo culture programmes body weight gain and raised blood pressure during early postnatal life
Miguel A. Velazquez, Bhavwanti Sheth, Stephanie J. Smith, Judith J. Eckert, Clive Osmond & Tom P. Fleming, 2018, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1864(2), 590-600
DOI: 10.1016/j.bbadis.2017.11.020
Type: article
Advanced maternal age causes adverse programming of mouse blastocysts leading to altered growth and impaired cardiometabolic health in post-natal life
M.A. Velazquez, C.G.C. Smith, N.R. Smyth, C. Osmond & Thomas Fleming, 2016, Human Reproduction, 31(9), 1970-80
DOI: 10.1093/humrep/dew177
Type: article
Regulation of ribosomal RNA expression across the lifespan is fine-tuned by maternal diet before implantation
Oleg Denisenko, Emma S. Lucas, Congshan Sun, Adam J. Watkins, Daniel Mar, Karol Bomsztyk & Tom P. Fleming, 2016, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1859(7), 906-913
DOI: 10.1016/j.bbagrm.2016.04.001
Type: article