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Research project

BBSRC Alcohol Dependence

Project overview

Using C elegans to identify molecular determinants of ethanol intoxication and withdrawal.

Staff

Lead researcher

Professor Lindy Holden-Dye BSc, MSc, PhD, FRSB, FBPhS

PROFESSOR OF NEUROSCIENCES

Research interests

  • Neuropharmacology
  • Invertebrate neuroscience
  • Nematode neurobiology
Connect with Lindy

Email: L.M.Holden-Dye@soton.ac.uk

Other researchers

Dr Steven Glautier

Associate Professor
Connect with Steven

Email: spg@soton.ac.uk

Professor Vincent O'connor

Professor of Neurochemistry

Research interests

  • Molecular mechanism of synaptic function and dysfunction
  • Synaptic degeneration
  • Genetic models of synaptic and neuronal dysfunction
Connect with Vincent

Email: V.M.OConnor@soton.ac.uk

Research outputs

Distinct molecular targets including SLO-1 and gap junctions are engaged across a continuum of ethanol concentrations in Caenorhabditis elegans
James Dillon, Ioannis Andrianakis, Richard Mould, Ben Ient, Wei Liu, Christopher James, Vincent O'Connor & Lindy Holden-Dye, 2013, The FASEB Journal, 27(10), 4266-4278
DOI: 10.1096/fj.11-189340
Type: article
NeuroChip: a microfluidic electrophysiological device for genetic and chemical biology screening of Caenorhabditis elegans adult and larvae
Chunxiao Hu, James Dillon, James Kearn, Caitriona Murray, Vincent O'Connor, Lindy Holden-Dye & Hywel Morgan, 2013, PLoS ONE, 8(5), e64297-[17pp]
DOI: 10.1371/journal.pone.0064297
Type: article
HSP-4 endoplasmic reticulum (ER) stress pathway is not activated in a C. elegans model of ethanol intoxication and withdrawal
Ben Ient, Richard Edwards, Richard Mould, Matthew Hannah, Lindy Holden-Dye & Vincent O'Connor, 2012, Invertebrate Neuroscience
DOI: 10.1007/s10158-012-0136-7
Type: article
A differential role for neuropeptides in acute and chronic adaptive responses to alcohol: behavioural and genetic analysis in caenorhabditis elegans
Philippa Mitchell, Richard Mould, James Dillon, Steven Glautier, Ioannis Andrianakis, Christopher James, Amanda Pugh, Lindy Holden-Dye, Vincent O'Connor & Anne C. Hart, 2010, PLoS ONE, 5(5), e10422
DOI: 10.1371/journal.pone.0010422
Type: article
AutoEPG: software for the analysis of electrical activity in the microcircuit underpinning feeding behaviour of caenorhabditis elegans
James Dillon, Ioannis Andrianakis, Kate Bull, Steve Glautier, Vincent O'Connor, L. Holden-Dye & C.J. James, 2009, PLoS ONE, 4(12), 1-13
DOI: 10.1371/journal.pone.0008482
Type: article