Research project

PRINCESS trial

Research groups:
Lead researchers:

Professor Philip Calder
Other researchers:

Professor Paul Little,

Emeritus Professor Michael Moore
Status:

Not active

Project overview

This study is now complete, please see associated publications. The PRINCESS trial will assess the efficacy and mechanisms of a nutritional intervention (daily probiotics) to enhance immune function and reduce infection in care home residents. This is anticipated to reduce antibiotic prescribing for common infectious diseases in a high-risk population.

Staff

Lead researchers

Professor Philip Calder

Head of School

Connect with Philip

Email: P.C.Calder@soton.ac.uk

Other researchers

Professor Paul Little

Professor in Primary Care Research

Connect with Paul

Email: P.Little@soton.ac.uk

Emeritus Professor Michael Moore

Connect with Michael

Email: mvm198@soton.ac.uk

Collaborating research institutes, centres and groups

Primary Care Research Centre

We are an internationally renowned centre of excellence known for conducting high-quality research to improve people’s lives. We inform and enhance evidence based primary health care in the UK and around the world.

Research outputs

Effect of probiotic use on antibiotic administration among care home residents: a randomized clinical trial

Christopher C. Butler Butler, Mandy Lau, David Gillespie, Eleri Owen-Jones, Mark Lown, Mandy Wootton, Philip Calder, Antony J. Bayer, Michael Moore, Paul Little, Jane Davies, Alison Edwards, Victoria Shepherd, Kerenza Hood, F. D. Richard Hobbs, Mina Davoudianfar, Heather Rutter, Helen Stanton, Rachel Lowe, Richard Fuller & Nick Francis, 2020, Journal of the American Medical Association, 324(1), 47-56

DOI: 10.1001/jama.2020.8556

Type: article