Research project

Modelling retinitis pigmentosa associated cone photoreceptor death using stem cell derived organoids

Lead researcher:

Dr Jorn Lakowski
Research funder:

The Academy of Medical Sciences
Status:

Not active

Staff

Lead researcher

Dr Jorn Lakowski

Lecturer

Research interests

Retinal Disease Modelling
Retinal Development
Drug Screening

Connect with Jorn

Email: J.Lakowski@soton.ac.uk

Research outputs

Microtubule modification defects underlie cilium degeneration in cell models of retinitis pigmentosa associated with pre-mRNA splicing factor mutations

Liliya Nazlamova, Suly Saray Villa Vasquez, Jenny Lord, Varshini Karthik, Man Kim Cheung, Jörn Lakowski & Gabrielle Wheway, 2022, Frontiers in Genetics, 13, 1009430

DOI: 10.3389/fgene.2022.1009430

Type: article

Generation of a cone photoreceptor-specific GNGT2 reporter line in human pluripotent stem cells

Liliya Nazlamova, Emma Jane Cassidy, Jane C. Sowden, Andrew Lotery & Jörn Lakowski, 2022, Stem cells (Dayton, Ohio), 40(2), 190-203

DOI: 10.1093/stmcls/sxab015

Type: article

NRL−/− gene edited human embryonic stem cells generate rod‐deficient retinal organoids enriched in S‐cone‐like photoreceptors

Elisa Cuevas, Daniel L. Holder , Ashwak H. Alshehri , Julie Tréguier , Jorn Lakowski & Jane C. Sowden, 2021, Stem Cells, 39(4), 414-428

DOI: 10.1002/stem.3325

Type: article