Research project

OPTIMISE - Optimising Treatment for Mild Systolic hypertension in the Elderly

Research groups:
Lead researchers:

Dr Mark Lown
Other researchers:

Professor Paul Little
Status:

Not active

Project overview

This study is now complete, please see associated publications. This is a Primary Care based, open label, randomised controlled trial with embedded qualitative components and the aims are: To safely reduce the amount of blood pressure medication taken by older people using self-monitoring of blood pressure. To see if reducing the amount of medication taken by older people results in fewer falls or other harmful events and side-effects. To see if reducing the number of blood pressure lowering medications can improve the quality of life of individuals entering older age.

Staff

Lead researchers

Dr Mark Lown

Associate Professor

Connect with Mark

Email: M.Lown@soton.ac.uk

Other researchers

Professor Paul Little

Professor in Primary Care Research

Connect with Paul

Email: P.Little@soton.ac.uk

Collaborating research institutes, centres and groups

Primary Care Research Centre

We are an internationally renowned centre of excellence known for conducting high-quality research to improve people’s lives. We inform and enhance evidence based primary health care in the UK and around the world.

Research outputs

Effect of antihypertensive medication reduction vs usual care on short-term blood pressure control in patients with hypertension aged 80 years and older: The OPTIMISE randomized clinical trial

James P. Sheppard, Jenni Burt, Mark Lown, Eleanor Temple, Rebecca Lowe, Rosalyn Fraser, Julie Allen, Gary A. Ford, Carl Heneghan, F. D.Richard Hobbs, Sue Jowett, Shahela Kodabuckus, Paul Little, Jonathan Mant, Jill Mollison, Rupert A. Payne, Marney Williams, Ly Mee Yu & Richard J. McManus, 2020, JAMA - Journal of the American Medical Association, 323(20), 2039-2051

DOI: 10.1001/jama.2020.4871

Type: article

OPtimising Treatment for MIld Systolic hypertension in the Elderly (OPTiMISE): protocol for a randomised controlled non-inferiority trial

Paul Little, james p sheppard, Jenni Burt, Mark Lown, Eleanor Temple, john benson, Gary A Ford, Carl Heneghan, FD Richard Hobbs, Sue Jowett, Jonathan Mant, Jill Mollison, Alecia Nickless, Emma Ogburn, Rupert Payne, Marney Williams, Ly-Mee Yu & Richard J. McManus, 2018, BMJ Open

DOI: 10.1136/bmjopen-2018-022930