Research project

Investigation of the epithelial-mescenchyme trophic unit (EMTU) in lung firbrosis

Lead researchers:

Professor Donna Davies
Research funder:

Medical Research Foundation
Status:

Not active

Staff

Lead researchers

Professor Donna Davies

Research interests

Mechanisms of lung diseases
Viral-induced exacerbations of lung disease
Asthma

Connect with Donna

Email: D.E.Davies@soton.ac.uk

Research outputs

Towards an artificial human lung

Maria Victoria Humbert, Cosma Mirella Spalluto, Joseph Bell, Cornelia Blume, Franco Conforti, Elizabeth R Davies, Lareb S N Dean, Paul Elkington, Hans Michael Haitchi, Claire Jackson, Mark G Jones, Matthew Loxham, Jane S Lucas, Hywel Morgan, Marta Polak, Karl J Staples, Emily J Swindle, Liku Tezera, Alastair Watson & Tom M A Wilkinson, 2022, The European respiratory journal, 60(6)

DOI: 10.1183/13993003.00455-2022

Type: article

Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis

Christopher J. Brereton, Liudi Yao, Elizabeth R. Davies, Yilu Zhou, Milica Vukmirovic, Joseph A. Bell, Siyuan Wang, Robert A. Ridley, Lareb S.N. Dean, Orestis G. Andriotis, Franco Conforti, Lennart Brewitz, Soran Mohammed, Timothy Wallis, Ali Tavassoli, Rob M. Ewing, Aiman Alzetani, Benjamin G. Marshall, Sophie V. Fletcher, Philipp J. Thurner, Aurelie Fabre, Naftali Kaminski, Luca Richeldi, Atul Bhaskar, Christopher J. Schofield, Matthew Loxham, Donna E. Davies, Yihua Wang & Mark G. Jones, 2022, eLife, 11

DOI: 10.7554/eLife.69348

Type: article

Bidirectional epithelial-mesenchymal crosstalk provides self-sustaining profibrotic signals in pulmonary fibrosis

Liudi Yao, Yilu Zhou, Juanjuan Li, Leanne Wickens, Franco Conforti, Anna Simron Rattu, Fathima M Ibrahim, Aiman Alzetani, Benjamin Marshall, Sophie Fletcher, David Hancock, Timothy Wallis, Julian Downward, Robert Ewing, Luca Richeldi, Paul Skipp, Donna Davies, Mark Glynne Jones & Yihua Wang, 2021, Journal of Biological Chemistry, 297(3)

DOI: 10.1016/j.jbc.2021.101096

Type: article

Paracrine SPARC signaling dysregulates alveolar epithelial barrier integrity and function in lung fibrosis

Franco Conforti, Robert Ridley, Christopher J Brereton, Aiman Alzetani, Mark Jones, Donna Davies, Paul Skipp, Yihua Wang, Christian Ottensmeier, B. Marshall, Sophie Fletcher, Luca Richeldi & Benjamin Johnson, 2020, Cell Death and Discovery, 6

DOI: 10.1038/s41420-020-0289-9

Type: article

Autophagy inhibition-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis

Charlotte Hill, Juanjuan Li, Dian Liu, Franco Conforti, Christopher J. Brereton, Liudi Yao, Yilu Zhou, Aiman Alzetani, Serena J. Chee, Ben G. Marshall, Sophie V. Fletcher, David Hancock, Christian H. Ottensmeier, Andrew J. Steele, Julian Downward, Luca Richeldi, Xin Lu, Donna E. Davies, Mark G. Jones & Yihua Wang, 2019, Cell Death and Disease, 10(8)

DOI: 10.1038/s41419-019-1820-x

Type: article