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Research project

Dr Vince O'Connor MRC TSE Highlight

Staff

Lead researchers

Professor Vincent O'connor

Professor of Neurochemistry

Research interests

  • Molecular mechanism of synaptic function and dysfunction
  • Synaptic degeneration
  • Genetic models of synaptic and neuronal dysfunction
Connect with Vincent

Email: V.M.OConnor@soton.ac.uk

Research outputs

Analysis of the hippocampal proteome in ME7 prion disease reveals a predominant astrocytic signature and highlights the brain-restricted production of clusterin in chronic neurodegeneration
Ayodeji A Asuni, Bryony Gray, Joanne Bailey, Paul Skipp, V Hugh Perry & Vincent O'Connor, 2014, The Journal of Biological Chemistry, 289(7), 4532-4545
DOI: 10.1074/jbc.M113.502690
Type: article
Brain region specific pre-synaptic and post-synaptic degeneration are early components of neuropathology in prion disease
Zuzana Šišková, Richard A. Reynolds, Vincent O'Connor & V. Hugh Perry, 2013, PLoS ONE, 8(1)
DOI: 10.1371/journal.pone.0055004
Type: article
The role of activity in synaptic degeneration in a protein misfolding disease, prion disease
Matteo Caleo, Laura Restani, Eleonora Vannini, Zuzana Siskova, Hussain Al-Malki, Ruth Morgan, Vincent O'Connor & V Hugh Perry, 2012, PLoS ONE, 7(7), e41182
DOI: 10.1371/journal.pone.0041182
Type: article
The role of microglia in synaptic stripping and synaptic degeneration: a revised perspective
V. Hugh Perry & Vincent O'Connor, 2010, ASN Neuro, 2(5), e00047-[11pp]
DOI: 10.1042/AN20100024
Type: article
Morphological and functional abnormalities in mitochondria associated with synaptic degeneration in prion disease
Zuzana Sisková, Don Joseph Mahad, Carianne Pudney, Graham Campbell, Mark Cadogan, Ayodeji Asuni, Vincent O'Connor & Victor Hugh Perry, 2010, The American Journal of Pathology, 177(3), 1411-1421
DOI: 10.2353/ajpath.2010.091037
Type: article