Research project

Dr P. Elkington: Investigating multi-drug resistant tuberculosis in the 3-dimensional bioelectrospray cell culture model

Lead researcher:

Professor Paul Elkington
Research funder:

Medical Research Council
Status:

Not active

Project overview

We will develop luminescent strains of multi-drug resistant tuberculosis and investigate the response to antibiotics in our biomimetic model system.

Staff

Lead researcher

Professor Paul Elkington

Director of Inst. for Medical Innovation

Research interests

tuberculosis
immunopathology
diagnosis

Connect with Paul

Email: P.Elkington@soton.ac.uk

Research outputs

Three-dimensional culture modelling reveals divergent Mycobacterium tuberculosis virulence and antimicrobial treatment response

Magdalena K. Bielecka, Liku B. Tezera, Eleni Konstantinopoulou, Nicola Casali, Orestis L. Katsamenis, Ximena Gonzalo, Francis Drobniewski & Paul T. Elkington, 2024, Cellular Microbiology

Type: article

Mycobacterium tuberculosis senses host Interferon-γ via the membrane protein MmpL10

Mohamed Ahmed, Jared Mackenzie, Liku Bekele Tezera, Robert Krause, Barry Truebody, Diana Garay Baquero, Andres Vallejo Pulido, Katya Govender, John Adamson, Hayden Fisher, Jonathan W. Essex, Salah Mansour, Paul Elkington, Adrie J. C. Steyn & Alasdair Leslie, 2022, Communications Biology, 5(1317)

DOI: 10.1038/s42003-022-04265-0

Type: article

Anti-tuberculosis activity of three carbapenems, clofazimine and nitazoxanide using a novel ex vivo phenotypic drug susceptibility model of human tuberculosis

Ximena Gonzalo, Magdalena K. Bielecka, Liku Bekele Tezera, Paul Elkington & Francis A. Drobniewski, 2022, Antibiotics, 11(10)

DOI: 10.3390/antibiotics11101274

Type: article

Doxycycline host-directed therapy in human pulmonary tuberculosis

Quig Miow, Andres Vallejo Pulido, Yu Wang, Jia Hong, Chen Bai, Felicia Teo, Alvin Wang, Hong Loh, Tuan Tan, Ying Ding, Hoi She, Suay Gan, Nicholas Paton, Josephine Lum, Alicia Tay, Cynthia Chee, Paul Tambyah, Marta Polak, Yee Wang, Amit Singhal, Paul Elkington, Jon S. Friedland & Catherine W.M. Ong, 2021, Journal of Clinical Investigation, 131(15)

DOI: 10.1172/JCI141895

Type: article

Personal respirators for population level control of the COVID19 pandemic

Paul Elkington & Hywel Morgan, 2020, Journal of Infection, 81(2), 318-356

DOI: 10.1016/j.jinf.2020.04.025

Type: letterEditorial