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Research project

Dr P. Elkington: Investigating multi-drug resistant tuberculosis in the 3-dimensional bioelectrospray cell culture model

Project overview

We will develop luminescent strains of multi-drug resistant tuberculosis and investigate the response to antibiotics in our biomimetic model system.

Staff

Lead researcher

Professor Paul Elkington

Director of Inst. for Medical Innovation

Research interests

  • tuberculosis
  • immunopathology
  • diagnosis

Research outputs

Mycobacterium tuberculosis senses host Interferon-γ via the membrane protein MmpL10
Mohamed Ahmed,
Jared Mackenzie,
Liku Bekele Tezera,
Robert Krause,
Barry Truebody,
Diana Garay Baquero,
Andres Vallejo Pulido,
Katya Govender,
John Adamson,
Hayden Fisher,
Jonathan W. Essex,
Salah Mansour,
Paul Elkington,
Adrie J. C. Steyn,
& Alasdair Leslie
, 2022 , Communications Biology , 5 (1317)
DOI: 10.1038/s42003-022-04265-0
Type: article
Anti-tuberculosis activity of three carbapenems, clofazimine and nitazoxanide using a novel ex vivo phenotypic drug susceptibility model of human tuberculosis
Ximena Gonzalo,
Magdalena K. Bielecka,
Liku Bekele Tezera,
Paul Elkington,
& Francis A. Drobniewski
, 2022 , Antibiotics , 11 (10)
DOI: 10.3390/antibiotics11101274
Type: article
Doxycycline host-directed therapy in human pulmonary tuberculosis
Quig Miow,
Andres Vallejo Pulido,
Yu Wang,
Jia Hong,
Chen Bai,
Felicia Teo,
Alvin Wang,
Hong Loh,
Tuan Tan,
Ying Ding,
Hoi She,
Suay Gan,
Nicholas Paton,
Josephine Lum,
Alicia Tay,
Cynthia Chee,
Paul Tambyah,
Marta Polak,
Yee Wang,
Amit Singhal,
Paul Elkington,
Jon S. Friedland,
& Catherine W.M. Ong
, 2021 , Journal of Clinical Investigation , 131 (15)
DOI: 10.1172/JCI141895
Type: article
Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-alpha
Liku Bekele Tezera,
Magdalena Bielecka,
Paul Ogongo,
Naomi Walker,
Matthew Ellis,
Diana J. Garay-Baquero,
Kristian Thomas,
MICHAELA REICHMANN,
David Johnston,
Katalin Wilkinson,
Mohamed Ahmed,
Sanjay Jogai,
Suwan N. Jayasinghe,
Robert J. Wilkinson,
Salah Mansour,
Gareth Thomas,
Christian Ottensmeier,
Alasdair Leslie,
& Paul Elkington
, 2020 , eLife , 9
DOI: 10.7554/eLife.52668
Type: article
Personal respirators for population level control of the COVID19 pandemic
Paul Elkington,
& Hywel Morgan
, 2020 , Journal of Infection , 81 (2) , 318--356
DOI: 10.1016/j.jinf.2020.04.025
Type: letterEditorial