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Research project

Dr Jane Cleal: Functional gene mapping of the endometrial phenotype involved in successful pregnancy: combining 3D imaging and single cell transcriptomics

Staff

Lead researcher

Dr Jane Cleal PhD

Associate Professor

Research interests

  • Areas of Scientific Expertise:
  • Reproductive Cell Biology – Fundamental mechanisms of cell biology in placenta and endometrium and the impact on the intra-uterine environment, fetal development and lifelong health.Regulation of Reproductive Cell Biology – Maternal exposures and molecular regulation of cellular gene expression, phenotype and function in placenta and endometrium and the clinical translation.Disease/phenotype – Fetal growth, Obesity, Cardiometabolic programming, Subfertility, Recurrent pregnancy loss.Cellular mechanisms – Membrane transport, endocytosis, vesicular transport & signalling, gene transcription, microRNA biology, epigenetic regulation.Vitamin D - Transport, regulation, metabolism and signalling.
Connect with Jane

Email: J.K.CLEAL@soton.ac.uk

Other researchers

Professor Rohan Lewis PhD, FTPS

Prof of Placental&Integrative Physiology
Connect with Rohan

Email: Rohan.Lewis@soton.ac.uk

Professor Ying Cheong

Professor of Reproductive Medicine
Connect with Ying

Email: Y.Cheong@soton.ac.uk

Research outputs

Ultrastructural cilia defects in multi-ciliated uterine glandular epithelial cells from women with reproductive failure
Jennifer E. Pearson-Farr, Regan Doherty, David S. Chatelet, Patricia Goggin, Ka Ying Bonnie Ng, Jane S. Lucas, Jane K. Cleal, Ying C. Cheong & Rohan M. Lewis, 2024, Reproduction, 167(1)
DOI: 10.1530/REP-23-0173
Type: article
Endometrial gland specific progestagen-associated endometrial protein and cilia gene splicing changes in recurrent pregnancy loss
Jennifer Pearson-Farr, Gabrielle Wheway, Maaike SA Jongen, Patricia Goggin, Rohan Lewis, Ying Cheong & Jane Cleal, 2022, Reproduction and Fertility, 3(3), 162-72
DOI: 10.1530/RAF-22-0002
Type: article
Microvillous tip vesicles may be an origin of placental extracellular vesicles
Rebecca Davies, Catherine Griffiths, Kathryn Askelund, Eleni Palaiologou, Jane K. Cleal, Anton Page, David S. Chatelet, Patricia Goggin, Larry Chamley & Rohan M. Lewis, 2022, Placenta, 123, 24-30
DOI: 10.1016/j.placenta.2022.04.003
Type: article
Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit
Brogan Ashley, Claire Simner, Antigoni Manousopoulou, Carl Jenkinson, Felicity Hey, Jennifer M. Frost, Faisal I Rezwan, Cory H White, Emma Lofthouse, Emily Hyde, Laura, Diana Frances Cooke, Sheila Barton, Pamela A Mahon, Elizabeth Curtis, Rebecca Moon, Sarah Crozier, Hazel Inskip, Keith Godfrey, John Holloway, Cyrus Cooper, Kerry S. Jones, Rohan Lewis, Martin Hewison, Spiros Garbis, Miguel R. Branco, Nicholas Harvey & Jane Cleal, 2022, eLife, 11
DOI: 10.7554/eLife.71094
Type: article
Multiscale three-dimensional imaging of the placenta
Rohan M. Lewis & Jennifer E. Pearson-Farr, 2020, Placenta, 102, 55-60
DOI: 10.1016/j.placenta.2020.01.016
Type: review