Research project

Characterising cancer-associated fibroblast heterogeneity in lung cancer: relating molecular phenotype to function

Lead researcher:

Professor Gareth Thomas
Other researchers:

Dr Chris Hanley
Research funder:

Medical Research Council
Status:

Not active

Staff

Lead researcher

Professor Gareth Thomas

Professor of Experimental Pathology

Research interests

Fibroblast biology and immunology
Tumour microenvironment
Cancer Immunotherapy

Connect with Gareth

Email: G.Thomas@soton.ac.uk

Other researchers

Dr Chris Hanley BSc, MRes, PhD

Lecturer in Quantitative Cell Biology

Research interests

Tumour microenvironment
Fibroblasts and the Extracellular Matrix
Quantitative Cell Biology

Connect with Chris

Email: C.J.Hanley@soton.ac.uk

Research outputs

Single-cell analysis reveals prognostic fibroblast subpopulations linked to molecular and immunological subtypes of lung cancer

Christopher J. Hanley, Sara Waise, Matthew J. Ellis, Maria A. Lopez, Wai Y. Pun, Julian Taylor, Rachel Parker, Lucy M. Kimbley, Serena J. Chee, Emily C. Shaw, Jonathan West, Aiman Alzetani, Edwin Woo, Christian H. Ottensmeier, Matthew J.J. Rose-Zerilli & Gareth J. Thomas, 2023, Nature Communications, 14

DOI: 10.1038/s41467-023-35832-6

Type: article

An optimised tissue disaggregation and data processing pipeline for characterising fibroblast phenotypes using single-cell RNA sequencing

Sara Waise, Rachel Parker, Matthew Rose-Zerilli, David Layfield, Oliver Wood, Jonathon West, Christian Ottensmeier, Gareth Thomas & Christopher Hanley, 2019, Scientific Reports, 9

DOI: 10.1038/s41598-019-45842-4

Type: article