Research project

Boche - ARUK - Locus coeruleus: its role in cortical and subcortical inflammation in Alzheimer's disease

Lead researchers:

Professor Delphine Boche
Other researchers:

Emeritus Professor Clive Holmes
Research funder:

Alzheimers Research UK
Status:

Not active

Staff

Lead researchers

Professor Delphine Boche

Professor of Neuroimmunopathology

Research interests

Neuroimmunology and neurodegeneration
Immunophenotyping immune cells
Human brain pathology

Connect with Delphine

Email: D.Boche@soton.ac.uk

Other researchers

Emeritus Professor Clive Holmes

Connect with Clive

Email: C.Holmes@soton.ac.uk

Research outputs

Changes in the locus Coeruleus during the course of Alzheimer’s disease and their relationship to cortical pathology

Rebecca Claire Beardmore, Matthew Durkin, Faizan Zayee-Mellick, Laurie C. Lau, James A.R. Nicoll, Clive Holmes & Delphine Boche, 2024, Neuropathology and Applied Neurobiology

Type: article

Neuropathology of the Locus Coeruleus in Alzheimer's disease

2022

Type: thesis

The locus coeruleus in aging and Alzheimer’s Disease: a postmortem and brain imaging review

Rebecca C Beardmore, Ruihua Hou, Angela Darekar, Clive Holmes & Delphine Boche, 2021, Journal of Alzheimer's Disease, 83(1), 5-22

DOI: 10.3233/JAD-210191

Type: review