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Research project

An integrated strategy for control of animal and plant parasitic nematodes through targeting MOD-1

Staff

Lead researchers

Professor Lindy Holden-Dye BSc, MSc, PhD, FRSB, FBPhS

PROFESSOR OF NEUROSCIENCES

Research interests

  • Neuropharmacology
  • Invertebrate neuroscience
  • Nematode neurobiology
Connect with Lindy

Email: L.M.Holden-Dye@soton.ac.uk

Other researchers

Professor Matthew Terry

Professor of Molecular Plant Biology

Research interests

  • Chloroplast development and retrograde signalling to the nucleus
  • Light regulation of wheat growth and development
  • Improving algal photosynthesis
Connect with Matthew

Email: mjt@soton.ac.uk

Professor Vincent O'connor

Professor of Neurochemistry

Research interests

  • Molecular mechanism of synaptic function and dysfunction
  • Synaptic degeneration
  • Genetic models of synaptic and neuronal dysfunction
Connect with Vincent

Email: V.M.OConnor@soton.ac.uk

Professor Mark Chapman

Professor
Connect with Mark

Email: M.Chapman@soton.ac.uk

Dr Herman Wijnen Drs, PhD, FHEA

Associate Professor

Research interests

  • Control of Daily Rhythms by Circadian Clocks and the Environment
  • Genetics, Behaviour and Neuroscience of the fruit fly Drosophila
  • Chronophysiology of Invertebrates in Association with Global Environmental Change and Food Security
Connect with Herman

Email: H.Wijnen@soton.ac.uk

Dr Declan Doyle

Senior Teaching Fellow
Connect with Declan

Email: D.A.Doyle@soton.ac.uk

Collaborating research institutes, centres and groups

Research outputs

PharmacoGenetic targeting of a C. elegans essential neuron provides an in vivo screening for novel modulators of nematode ion channel function
Fernando Calahorro, Mark Chapman, Katarzyna Dudkiewicz, Lindy Holden-dye & Vincent O'connor, 2022, Pesticide Biochemistry and Physiology, 186
DOI: 10.1016/j.pestbp.2022.105152
Type: article
Confounds of using the unc-58 selection marker highlights the importance of genotyping co-CRISPR genes
James Dillon & Helena Rawsthorne-Manning, 2022, PLoS ONE, 17(1 January)
DOI: 10.1371/journal.pone.0253351
Type: article
Cholinergic signaling at the body wall neuromuscular junction distally inhibits feeding behavior in Caenorhabditis elegans
Patricia G. Izquierdo, Fernando Calahorro, Thibana Thisainathan, James H. Atkins, Johanna Haszczyn, Christian J. Lewis, John E.h. Tattersall, A. Christopher Green, Lindy Holden-dye & Vincent O'connor, 2022, Journal of Biological Chemistry, 298(1), 101466
DOI: 10.1016/j.jbc.2021.101466
Type: article
Impact of drug solvents on C. elegans pharyngeal pumping
Fernando Calahorro Nunez, Linda Holden-Dye & Vincent O'connor, 2021, Toxicology Reports, 8, 1240-1247
DOI: 10.1016/j.toxrep.2021.06.007
Type: article