Research group

Microfluidics and Sensors

Two fingers wearing globes holding a microchip

Microfluidics is the interdisciplinary study of the behaviour, manipulation and application of fluid at the microscale. It underpins the concept of the lab-on-a-chip, where multiple key components and operations are integrated onto one small platform.

About

 

This is an important underlying technology with applications across a diverse range of fields including medicine, chemistry and oceanic research. 

Scientists across the Institute of Life Sciences have been driving microfluidics research and application forward for more than two decades. With a translational approach many of our fundamental science discoveries have resulted in novel micro-engineered devices which have paved the way for how patients are treated in hospital.  

Our research teams span fields from engineering and physics to medicine and biology and are carrying out research into areas such as single cell analysis, organ-on-a-chip, neuroscience, clinical diagnostics, personalised medicine and environmental monitoring. Our scientists use microfluidic devices and systems to find solutions to some of today’s biggest challenges including antimicrobial resistance and ocean climate changes. 

As well as using microfluidics to provide engineering solutions for biological and healthcare applications our scientists are also training the next generation of microfluidics experts. Our postgraduate students work alongside international leaders in their field, shaping and developing research projects as well as conducting their own research investigations. 

Staff and students alike also have access to cutting-edge facilities which contain state of the art analytical equipment, dedicated cell and tissue culture laboratory and rapid prototyping clean rooms. 

People, projects and publications

People

Professor Ivan Haigh

Professor

Research interests

  • I currently have 8 active research grants (4 as principle investigator (PI)) worth £4.8M. 
  • I am the PI on two international grants that started in 2019, both looking at compound flooding. Compound flooding (when the combination, or successive occurrence of, two or more hazard events leads to an extreme impact e.g., coastal and fluvial flooding), can greatly exacerbate the adverse consequences associated with flooding in coastal regions and yet it remains under-appreciated and poorly understood. In the £788k NERC- and NSF- (US National Science Foundation) funded CHANCE project, I am leading a team (working alongside researchers from the University of Central Florida), to deliver a new integrated approach to make a step-change in our understanding, and prediction of, the source mechanisms driving compound flood events in coastal areas around the North Atlantic basin. In the £575k NERC- and NAFOSTED- (Vietnam’s National Foundation for Science and Technology Development) funded project, I am leading a team that is working with colleagues in Vietnam to map and characterise present, and predict future, flood risk from coastal, fluvial, and surface sources and, uniquely, to assess the risk of compound flooding across the Mekong delta; one of the three most vulnerable deltas in the world. I am also the PI on a grant, which started in 2021. In this 41k project, funded by the Dutch Ministry of Infrastructure and Water Management (Rijkswaterstaat), we are assessing past and future closures of the six storm surge barriers in the Netherlands.
  • In 2021, I was awarded a 3-year (50% of my time) prestigious Knowledge Exchange Fellowship funded by NERC (UK’s Natural Environmental Research Council) and worth £154k. This fellowship builds strongly on my prior research and the overall goal is to provide guidance and tools that will help storm surge barrier operators better prepare for the impacts of climate change across every area of their operation now and into the future. Within the fellowship I am working primary with the UK Environment Agency (EA) and the Dutch Ministry of Infrastructure and Water Management (Rijkswaterstaat). However, to ensure the work undertaken can benefit all the existing (and planned) surge barriers around the world, I am also working closely with I-STORM. I-STORM is an international knowledge sharing network for professionals relating to the management, operation and maintenance of storm surge barriers, and has representation from all the surge barriers worldwide.

Accepting applications from PhD students

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Professor Ivo Tews

Professor

Research interests

  • Natural products biosynthesis: a complex cascade of catalytic steps in vitamin B6 biosynthesis is characterised by structures or reaction intermediates in the large PLP syntase complexEdit
  • Bacterial biofilms: understanding of RedOx regulated phosphodiesterase activity in dispersal of biofilms to address chronic infections
  • Cancer immunology: together with Cancer Immunology at Southampton we use a structure based apporach in developing novel cancer therapie
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Professor Jacek Brodzki

Head of School

Research interests

  • Topological data analysis
  • Applications of topology to medicine, biology, chemistry, physics, computer science
  • Noncommutative Geometry

Accepting applications from PhD students

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Mr Jack Stubbs MSci

Research interests

  • Natural products biosynthesis: a complex cascade of catalytic steps in vitamin B6 biosynthesis is characterised by structures or reaction intermediates in the large PLP synthase complexTime-resolved serial crystallography: experiments using microcrystals at room temperature, performed at synchrotrons and XFELsDroplet microfluidics: producing homogenous microcrystal slurries for serial experiments
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Dr Jacqui Prieto RN, PhD

Associate Professor

Research interests

  • Preventing urinary tract infection and catheter-associated urinary tract infection
  • Optimising hygiene behaviours in healthcare
  • Understanding patients' experiences of healthcare associated infection

Accepting applications from PhD students

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Dr Jagmohan Chauhan

Lecturer in Computer Science

Research interests

  • Digital healthcare
  • Embedded AI
  • Sensing

Accepting applications from PhD students

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Dr James Ashton

Associate Professor

Research interests

  • Inflammatory Bowel Disease
  • Paediatrics
  • Big Data

Accepting applications from PhD students

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Professor James Batchelor

Associate Dean International

Research interests

  • Public Health / Health Systems
  • Clinical Research Infastrcuture
  • Clinical Informatics / Health Infromatics

Accepting applications from PhD students

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Dr James Gavin

Lecturer

Research interests

  • Musculoskeletal conditions
  • Physical activity
  • Self-management

Accepting applications from PhD students

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Interdisciplinary research teams collaborate across engineering technologies with applications in medicine, biology and environment to create novel and disruptive research activity in areas including diagnostics, infectious diseases and water testing.
Professor of Bioelectronics

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