Professor Primrose’s research is in gastrointestinal cancer, clinical and translational and Health Services Research. The focus is on improving outcomes for patients undergoing surgical treatment for cancer. This is being achieved through devising and undertaking large scale national and international trials. All the studies are associated with tissue collections with a view to the development of biomarkers which will have prognostic value and may also predict response to therapy.
Time-Resolved Structural Biology
The emergence of serial crystallography brings many exciting possibilities for structural biology but also brings the challenge of preparing many thousands of sub-micron crystals. To address this, we are working with Ivo Tews and Allen Orville to develop high throughput droplet microfluidic systems. Here volumetric confinement of the phase diagram defines growth limits for producing monodisperse protein crystals. Beyond this, the microfluidic processors can be interfaced with the beam line to enable dynamic structural biology.
