About
A brief description of who you are and what you do.
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Write about yourself in the third person. Aim for 100 to 150 words covering the main points about who you are and what you currently do. Clear, simple language is best. You can include specialist or technical terms.
You’ll be able to add details about your research, publications, career and academic history to other sections of your staff profile.
Research
Research interests
- Graft-versus-host disease
- Haematopoietic stem cell transplantation
- The interplay between the gut microbiome and the immune system
- Obesity and the related metabolic diseases
Current research
Allogeneic hematopoietic stem cell transplantation (HSCT) is a cancer immunotherapy because it induces the graft-versus-tumor (GVT) effect, whereby donor-derived cells attack the host’s hematologic malignant cells. However, disadvantages of allo-HSCT include the difficulty in finding a suitable donor and the potential for damage to the recipient’s normal tissues due to immunological attacks by alloreactive donor-derived T cells, a process known as graft-versus-host disease (GVHD).
In collaboration with Professor Simón Méndez-Ferrer (University of Cambridge), my current study investigates the regulatory mechanisms of cholinergic signaling in generating GVH responses from donor lymphocytes in both mice and humans. Building on our preclinical models and clinical observations, this research has the potential to propose a promising target for reducing the risk of GVHD pathogenesis following allogeneic HSCT.
During my PhD and postdoctoral training in the United States with Distinguished Professor William J. Murphy at the University of California, Davis, I observed that obesity, a common pre-existing condition in transplant recipients, could skew the microbiome towards pathogenic bacteria, such as Akkermansia muciniphila, which in turn predisposed these recipients to more severe GVHD responses post-transplantation. Although the study elucidated only a partial mechanism by which obesity facilitates GVHD pathogenesis, it provided valuable insights into potential therapeutic targets and an innovative strategy: reducing pathogenic bacteria pre-transplant to improve HSCT outcomes. I aim to expand this research direction to establish an optimized strategy for "fine-tuning" the host microbiome pre-transplant, potentially benefiting HSCT recipients through diet modulation.
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Research groups
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Research interests
Add up to 5 research interests. The first 3 will appear in your staff profile next to your name. The full list will appear on your research page. Keep these brief and focus on the keywords people may use when searching for your work. Use a different line for each one.
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Current research
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Describe your current research in 100 to 200 words. Write in the third person. Include broad key terms to help people discover your work, for example, “sustainability” or “fashion textiles”.
Research projects
Research Council funded projects will automatically appear here. The active project name is taken from the finance system.
Publications
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Supervision
A list of your current and past PhD students.
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Contact your Faculty Operating Service team to update PhD students you supervise and any you’ve previously supervised. Making this information available will help potential PhD applicants to find you.
Teaching
A short description of your teaching interests and responsibilities.
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Courses and modules
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External roles and responsibilities
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Biography
Dr. Lam T. Khuat completed his PhD and postdoctoral training in the United States with Distinguished Professor William J. Murphy at the University of California, Davis, where his research focused on investigating the role of obesity-induced microbiota in graft-versus-host disease (GVHD) outcomes following haematopoietic stem cell transplantation (HSCT). He then joined the University of Cambridge to work with Professor Simón Méndez-Ferrer on cholinergic signalling and its regulation of allogeneic responses in normal haematopoiesis and GVHD. Dr. Khuat is currently a Senior Research Fellow in the Antibody and Vaccine Group, Centre for Cancer Immunology, where his research continues to explore how dietary modulation influences the host microbiome and donor-derived immune cell responses in HSCT.
You can update your biography section in Pure (opens in a new tab). Select your ‘Personal’ tab then ‘Edit profile’. Under the heading, and ‘Curriculum and research description’, select ‘Add profile information’. In the dropdown menu, select - ‘Biography’. Aim for no more than 400 words.
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Prizes
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