About
Simon Crabb is a Professor of Experimental Cancer Therapeutics within the School of Cancer Sciences and an Honorary Consultant in Medical Oncology at University Hospital Southampton NHS Foundation Trust. His research is focused on novel treatment options for cancer. This includes interests in precision medicine approaches for bladder and prostate cancers, mechanisms of cancer therapy resistance and epigenetic therapeutics. Professor Crabb is the Associate Clinical Director of Southampton Clinical Trials Unit and Clinical Programme Lead for Southampton Experimental Cancer Medicine Centre. His external roles have included Chairmanship of the Genomics England Clinical Interpretation Partnership for bladder cancer and memberships of the NCRI Bladder and Renal Group, the NCRI Prostate Group and the Experimental Medicine Expert Review Panel for Cancer Research UK.
Research
Research groups
Member of:
Research interests
- Bladder cancer
- Prostate cancer
- Predictive biomarkers
- Precision medicine
- Early phase cancer clinical trials
Current research
Prof Crabb is an active contributor to the UK academic clinical trials portfolio with interests that span from first in human through to definitive phase III studies and with a strong emphasis on translational endpoints. He is the Chief Investigator for multiple clinical trials in urological malignancies.
Research projects
Active projects
Researchers:
Sponsor: Cancer Research UK
Researchers:
Researchers:
Researchers:
Sponsor: Cancer Research UK
Researchers:
Sponsor: Cancer Research UK
Researchers:
Sponsor: Queen's University at Kingston
Researchers:
Sponsor: Cancer Research UK
Completed projects
Researchers:
Sponsor: Cancer Research UK
Researchers:
Sponsor: Cancer Research UK
Researchers:
Sponsor: SAKK - Swiss Group for Clinical Cancer Research
Sponsor: Wessex Medical Research
Researchers:
Sponsor: Wessex Medical Research
Researchers:
Sponsor: Astex Pharmaceuticals, Inc.
Researchers:
Sponsor: Prostate Cancer UK
Researchers:
Sponsor: Plexxikon Inc
Researchers:
Sponsor: Cancer Research UK
Researchers:
Sponsor: Cancer Research UK
Researchers:
Sponsor: Cancer Research UK
Publications
124 publications
Page 5 of 13
J. Alfred Witjes, Marek Babjuk, Joaquim Bellmunt, H. Maxim Bruins, Theo M. De Reijke, Maria De Santis, Silke Gillessen, Nicholas James, Steven Maclennan, Juan Palou, Tom Powles, Maria J. Ribal, Shahrokh F. Shariat, Theo Van Der Kwast, Evanguelos Xylinas, Neeraj Agarwal, Tom Arends, Aristotle Bamias, Alison Birtle, Peter C Black, Bernard H Bochner, Michel Bolla, Joost L. Boormans, Alberto Bossi, Alberto Briganti, Iris Brummelhuis, Max Burger, Daniel Castellano, Richard Cathomas, Arturo Chiti, Ananya Choudhury, Eva Compérat, Simon Crabb, Stephane Culine, Berardino De Bari, Willem De Blok, Pieter J.L. De Visschere, Karel Decaestecker, Konstantinos Dimitropoulos, Jose L. Dominguez-Escrig, Stefano Fanti, Valerie Fonteyne, Mark Frydenberg, Jurgen J. Futterer, Georgios Gakis, Bogdan Geavlete, Paolo Gontero, Bernhard Grubmüller, Shaista Hafeez, Donna E. Hansel, Arndt Hartmann, Dickon Hayne, Ann M. Henry, Virginia Hernandez, Harry Herr, Ken Herrmann, Peter Hoskin, Jorge Huguet, Barbara A. Jereczek-Fossa, Rob Jones, Ashish M. Kamat, Vincent Khoo, Anne E. Kiltie, Susanne Krege, Sylvain Ladoire, Pedro C. Lara, Annemarie Leliveld, Estefania Linares-Espinós, Vibeke Løgager, Anja Lorch, Yohann Loriot, Richard Meijer, M. Carmen Mir, Marco Moschini, Hugh Mostafid, Arndt-Christian Müller, Christoph R Müller, James N'Dow, Andrea Necchi, Yann Neuzillet, Jorg R Oddens, Jan Oldenburg, Susanne Osanto, Wim J.G. Oyen, Luís Pacheco-Figueiredo, Helle Pappot, Manish I. Patel, Bradley R. Pieters, Karin Plass, Mesut Remzi, Margitta Retz, Jonathan Richenberg, Michael Rink, Florian Roghmann, Jonathan E. Rosenberg, Morgan Rouprêt, Olivier Rouvière, Carl Salembier, Antti Salminen, Paul Sargos, Shomik Sengupta, Amir Sherif, Robert J. Smeenk, Anita Smits, Arnulf Stenzl, George N. Thalmann, Bertrand Tombal, Baris Turkbey, Susanne Vahr Lauridsen, Riccardo Valdagni, Antoine G. Van Der Heijden, Hein Van Poppel, Mihai D. Vartolomei, Erik Veskimäe, Antoni Vilaseca, Franklin A Vives Rivera, Thomas Wiegel, Peter Wiklund, Andrew Williams, Richard Zigeuner & Alan Horwich,
2020, European Urology, 77(2), 223-250
Type: article
A. Horwich, M. Babjuk, J. Bellmunt, H.M. Bruins, T.M. De Reijke, M. De Santis, S. Gillessen, N. James, S Maclennan, J. Palou, T Powles, M.J. Ribal, S.F. Shariat, T. Van Der Kwast, E. Xylinas, N. Agarwal, T. Arends, A. Bamias, A. Birtle, P.C. Black, B.H. Bochner, M Bolla, J L Boormans, A Bossi, A Briganti, I Brummelhuis, M Burger, D Castellano, R Cathomas, A Chiti, A Choudhury, E Compérat, S Crabb, S Culine, B De Bari, W De Blok, P J L De Visschere, K Decaestecker, K Dimitropoulos, J L Dominguez-Escrig, S Fanti, V Fonteyne, M Frydenberg, J J Futterer, G Gakis, B Geavlete, P Gontero, B Grubmüller, S Hafeez & A M Henry,
2020, Annals of Oncology, 30(11), 1697-1727
Type: article
Andrew Davies, Christopher Mansbridge, Peter Simmonds, Nicholas Murray, Louise Stanton, Fay Chinnery, Caroline Archer, Peter Barrett-Lee, Tamas Hickish & Simon Crabb,
2020, F1000 Research
Type: article
Joaquin Mateo, Nuria Porta, Diletta Bianchini, Ursula McGovern, Tony Elliott, Robert Jones, Isabel Syndikus, Christy Ralph, Suneil Jain, Mohini Varughese, Omi Parikh, Simon Crabb, Angus Robinson, Duncan McLaren, Alison Birtle, Jacob Tanguay, Susana Miranda, Ines Figueiredo, George Seed, Claudia Bertan, Penny Flohr, Berni Ebbs, Pasquale Rescigno, Gemma Fowler, Ana Ferreira, Ruth Riisnaes, Rita Pereira, Andra Curcean, Robert Chandler, Matthew Clarke, Bora Gurel, Mateus Crespo, Daniel Nava Rodrigues, Shahneen Sandhu, Aude Espinasse, Peter Chatfield, Nina Tunariu, Wei Yuan, Emma Hall, Suzanne Carreira & Johann S de Bono,
2020, Lancet Oncology, 21(1), 162-174
Type: article
Matteo Santoni, Daniel Y. Heng, Sergio Bracarda, Giuseppe Procopio, Michele Milella, Camillo Porta, Marc R. Matrana, Giacomo Cartenì, Simon J. Crabb, Ugo De Giorgi, Umberto Basso, Cristina Masini, Fabio Calabrò, Maria Giuseppa Vitale, Daniele Santini, Francesco Massari, Luca Galli, Giuseppe Fornarini, Riccardo Ricotta, Sebastiano Buti, Paolo Zucali, Orazio Caffo, Franco Morelli, Francesco Carrozza, Angelo Martignetti, Alain Gelibter, Roberto Iacovelli, Alessandra Mosca, Francesco Atzori, Nuno Vau, Lorena Incorvaia, Cinzia Ortega, Marina Scarpelli, Antonio Lopez-Beltran, Liang Cheng, Vittorio Paolucci, Jeffrey Graham, Erin Pierce, Sarah Scagliarini, Pierangela Sepe, Elena Verzoni, Sara Merler, Mimma Rizzo, Giulia Sorgentoni, Alessandro Conti, Francesco Piva, Alessia Cimadamore, Rodolfo Montironi & Nicola Battelli,
2019, Cancers, 12(1)
Type: article
Emma Clark, Miranda Morton, Shriya Sharma, Holly Fisher, Denise Howel, Jenn Walker, Ruth Wood, Helen Hancock, Rebecca Maier, John Marshall, Amit Bahl, Simon Crabb, Suneil Jain, Ian Pedley, Rob Jones, John Staffurth & Rakesh Heer,
2019, BMJ Open, 9(12)
Type: article
Thomas Powles, Mark Kockx, Alejo Rodriguez-Vida, Ignacio Duran, Simon J. Crabb, Michiel S Van Der Heijden, Bernadett Szabados, Albert Font Pous, Gwenaelle Gravis, Urbano Anido Herranz, Andrew Protheroe, Alain Ravaud, Denis Maillet, Maria Jose Mendez, Cristina Suarez, Mark Linch, Aaron Prendergast, Pieter-Jan van Dam, Diana Stanoeva, Sofie Daelemans, Sanjeev Mariathasan, Joy S. Tea, Kelly Mousa, Romain Banchereau & Daniel Castellano,
2019, Nature Medicine, 25(11), 1706-1714
Type: letterEditorial
A Bamias, K Tzannis, L C Harshman, S J Crabb, S Kumar Pal, U De Giorgi, S Ladoire, N Agarwal, E Y Yu, G Niegisch, A Necchi, C N Sternberg, S Srinivas, A Alva, U Vaishampayan, L Cerbone, M Liontos, J Rosenberg, T Powles, J Bellmunt & M D Galsky,
2019, Annals of Oncology, 30(11), 1841
Type: article
Joep J. de Jong, Yang Liu, A. Gordon Robertson, Roland Seiler, Clarice S. Groeneveld, Michiel S. van der Heijden, Jonathan L. Wright, James Douglas, Marc Dall'Era, Simon J. Crabb, Bas W.G. van Rhijn, Kim E.M. van Kessel, Elai Davicioni, Mauro A.A. Castro, Yair Lotan, Ellen C. Zwarthoff, Peter C. Black, Joost L. Boormans & Ewan A. Gibb,
2019, Genome Medicine, 11(1), 1-13
Type: article
Alberto Martini, Rachel Jia, Bart S. Ferket, Nikhil Waingankar, Elizabeth R. Plimack, Simon J. Crabb, Lauren C. Harshman, Evan Y. Yu, Thomas Powles, Jonathan E. Rosenberg, Sumanta K. Pal, Ulka N. Vaishampayan, Andrea Necchi, N. Peter Wiklund, Reza Mehrazin, Madhu Mazumdar, John P. Sfakianos & Matthew D. Galsky,
2019, Cancer, 125(18), 3155-3163
DOI: 10.1002/cncr.32169
Type: article
External roles and responsibilities
Name:
Cancer Research UK Experimental Medicine Expert Review Panel (External organisation)
Role:
Member
Year:
2015 - 2021
Name:
National Cancer Research Institute Bladder and Renal Group (External organisation)
Role:
Member
Year:
2012 - 2021
Name:
National Cancer Research Institute Prostate Group (External organisation)
Role:
Member
Year:
2012 - 2021
Name:
National Cancer Research Institute Advanced Bladder Cancer Subgroup (External organisation)
Role:
Chair
Year:
2014 - 2018
Name:
Bladder Cancer Genomics England Clinical Interpretation Partnership (External organisation)
Role:
Chair
Year:
2016 -
Name:
British Association for Cancer Research Executive Committee (External organisation)
Role:
Member
Year:
2012 - 2015
Name:
Experimental Cancer Medicine Centre (External organisation)
Role:
Member
Year:
2015 - 2020
Name:
International Rare Cancers Initiative Genitourinary Cancers Group (External organisation)
Role:
Member
Year:
2018 -
Name:
British Journal of Cancer (Journal)
Role:
Member of editorial board
Year:
2023 -
Biography
Prof Crabb graduated in Medicine from St George’s Hospital Medical School in 1996 and joined the University in 2002 as a Cancer Research UK Clinical Research Fellow. His PhD was awarded in 2006 for research on the pre-clinical development of histone deacetylase inhibitors. This was followed by post-doctoral training as a Clinical Research Fellow at the BC Cancer Agency in Vancouver and the Cancer Research UK Centre in Southampton. He was appointed as an Honorary Consultant in Medical Oncology at University Hospital Southampton NHS Foundation Trust in 2009, with specialist clinical interests in bladder, prostate and adrenal cancers. He is a lead for early phase cancer clinical trials for solid malignancies and established the UHS early phase cancer trials clinic.