Module overview
Linked modules
Pre-requisite: CHEM2026 and CHEM2032
Aims and Objectives
Learning Outcomes
Learning Outcomes
Having successfully completed this module you will be able to:
- Describe how metals can be utilised in medical applications from both a therapeutic and diagnostic perspective.
- Demonstrate detailed appreciation of the challenges and solutions associated with the successful preparation of macrocycles with a range of donor atom types (O, N, S, Se, P) and their complexes, as well as developing the necessary skills in analysing and interpreting spectroscopic and analytical data on these systems, so that previously unseen examples and/or reaction schemes may be correctly identified and rationalised.
- Be able to provide a sound basis for the macrocyclic effect in terms of both kinetic and thermodynamic considerations, and link this closely to the potential and actual applications of macrocyclic systems in a range of domains, including a detailed understanding of the key factors influencing the design of macrocyclic frameworks suitable for the selective extraction of particular metal ions (s-block, p-block and 1st row d-block).
- Demonstrate an appreciation of how and why macrocyclic ligands can support coordination of metal ions in unusual oxidation states, how to optimise these characteristics for particular metals and their development towards electrocatalysis.
- Describe in detail how metal ions are important in biological processes and why the coordination environment around the metal centre plays a crucial role in its function.
Syllabus
Learning and Teaching
Teaching and learning methods
| Type | Hours |
|---|---|
| Blended Learning | 36 |
| Revision | 24 |
| Preparation for scheduled sessions | 36 |
| Problem Classes | 12 |
| Follow-up work | 42 |
| Total study time | 150 |
Resources & Reading list
Journal Articles
S. Faulkner and N. Long (2011). Radiopharmaceuticals for Imaging and Therapy. Dalton Trans., 40, pp. 6067.
L.F. Lindoy, G.V. Meehan, I.M. Vasilescu, H.J. Kim, J.-E. Lee, S.S. Lee (2010). Transition and post-transition metal ion chemistry of dibenzo-substituted, mixed-donor macrocycles incorporating five donor atoms. Coord Chem. Rev., 254, pp. 1713.
J. A. McCleverty and T. J. Meyer (2004). Thioether, Selenoether and Telluroether Macrocycles. Comprehensive Coordination Chemistry II, 1, pp. 399.
T. Johnstone, K. Suntharalingam, and S. J. Lippard (2016). The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs. Chem. Rev., 116 (5), pp. 3436.
J. A. McCleverty and T. J. Meyer (2004). Phosphine and Arsine Macrocycles. Comprehensive Coordination Chemistry II, 1, pp. 475.
Textbooks
J. C. Dabrowiak (2009). Metals in Medicine. John Wiley & Sons, Ltd..
R. K. Zalups, D. J. Koropatnick (2010). Cellular and Molecular Biology of Metals. CRC Press.
D. E. Fenton (1995). Biocoordination Chemistry. Oxford University Press.
E.C. Constable (1999). The Coordination Chemistry of Macrocyclic Compounds. Oxford Chemistry Primer No 72, OUP.
P.C. Wilkins and R.G. Wilkins (1997). Inorganic Chemistry in Biology. Oxford Chemistry Primer 46, OUP.
L.F. Lindoy (1989). The Chemistry of Macrocyclic Ligand Complexes. Cambridge: Cambridge University Press.
Assessment
Assessment strategy
Assessment is through a combination of coursework (through two tests, each 10% of module assessment) and an end of module examination that allows students to demonstrate the knowledge, understanding and problem solving skills developed through the module.Summative
This is how we’ll formally assess what you have learned in this module.
| Method | Percentage contribution |
|---|---|
| Coursework | 20% |
| Final Exam | 80% |
Referral
This is how we’ll assess you if you don’t meet the criteria to pass this module.
| Method | Percentage contribution |
|---|---|
| Final Exam | 80% |
| Coursework marks carried forward | 20% |
Repeat Information
Repeat type: Internal & External