Chemical Engineering for the Pharmaceutical Sector

Learning Outcomes

Subject Specific Practical Skills

Having successfully completed this module you will be able to:

• Evaluate the outcomes of risk assessments for a series of case studies of pharmaceutical production processes (Breadth)
• Select and utilise appropriate chemical engineering tools to model complex Heat and Mass transfer processes. (Design);

Knowledge and Understanding

Having successfully completed this module, you will be able to demonstrate knowledge and understanding of:

• Discuss the stages of the formulation process with reference to case studies
• Extend and apply knowledge of design practices to describe the primary operating parameters in current pharmaceutical industries;

Disciplinary Specific Learning Outcomes

Having successfully completed this module you will be able to:

• Apply and evaluate concepts and limitations of chemical engineering drug processing (Practice)
• Reflect on the sustainability and impact of current and emerging processes. (Emerging technologies);
• Evaluate the effects of uncertainty in the production of pharmaceutical products and devise strategies to mitigate the risks of such uncertainty (Depth)
• Assess the impacts of health and safety, with respect to current legal requirements. (Breadth) ;
• Analyse the parameters required for a complete life cycle analysis in the context of water use and energy in pharmaceutical sectors and technology. (Design)
• Evaluate the use of process control, catalysis and reaction to optimise current pharmaceutical processing practices. (Practice);

Subject Specific Intellectual and Research Skills

Having successfully completed this module you will be able to:

• Select and design unit operations appropriate to the manufacture of specific classes of pharmaceutical products

UNIT I - INTRODUCTION

Development of drugs and pharmaceutical industry; Organic therapeutic agents uses and Economics; Drug Metabolism and Pharmaco Kinetics; Drug Metabolism: Physio Chemical principles; Radioactivity; Pharma kinetic reaction of Drugs on Human bodies. In depth understanding of the environmental and safety aspects processing operations.

UNIT II - IMPORTANT UNIT PROCESS AND THEIR APPLICATIONS

Chemical conversion processes; Alkylation; Carboxylation; Condensation & Cyclisation; Dehydration; Esterification; Halogenation; Oxidation; Sulfonation; Complex Chemical conversions; Fermentation.

UNIT III - MANUFACTURING PRINCIPLES & EMULSIONS

Compressed Tablets; Wet granulation - dry granulation or slugging; Direct compression Tablet Presses Formulation; Coating Pills; Capsules; Sustained dosage Forms; Parental Solution; Oral liquids - Injections External preparations - Ointments; Standard of Hygiene and Good Manufacturing practice as per Drugs & Cosmetics Act as amended update.

UNIT IV - PHARMACEUTICAL PRODUCTS FORMULATIONS

Based on Antipyretic & anti inflammatory, Respiratory, Cardio intestinal & Liver, Hormones, C.N.S Stimulants, Histamine and Anti Histamine, Vitamins and other nutrients, Sedatives, Analgesics. Computational Chemistry and drug analysis

UNIT V - MICROBIOLOGICAL & ANIMAL PRODUCTS

Antibiotics, Anti Infective, Biological, Hormones, Vitamins and Preservation, Pharmaceutical Analysis, Analytical methods and Tests for various Drugs and Pharmaceuticals, Packing Techniques, Quality Control.

Teaching is by a combination of formal lectures augmented by problem solving sessions

Summative

This is how we’ll formally assess what you have learned in this module.