Regulation of Gene Expression

Learning Outcomes

Learning Outcomes

Having successfully completed this module you will be able to:

• An ability to critically evaluate and discuss original research articles in the area of gene regulation 
• Explain how transcriptional control is achieved through alterations in chromatin structure and methylation
• Outline the mechanisms by which post-transcriptional control is achieved.
• Explain the mechanism by which transcription is initiated in eukaryotic cells
• Illustrate methods to identify key regulatory elements within a eukaryotic promoter
• Outline the mechanisms and factors that control the process of translation.
• Explain the structure, formation and function of microRNAs

This module covers the structure and expression of genetic material in eukaryotic cells. Regulation of eukaryotic gene expression will be discussed. Selected examples where gene expression has been disrupted will also be covered; this will include the study of transcription factors as oncogenes and tumour suppressor genes. . In subsequent lectures the role of microRNAs in gene regulation and disease will be discussed, together with the factors and mechanisms that control the process of translation.

This course comprises

i) Lectures and feedback/revision seminars. (For each section of the course the student is given a comprehensive reading list of recent research and review papers).

ii) A critical evaluation (2000 words) and oral presentation on an agreed research article from the current literature related to this topic.

iii) A written 2 hour examination

Summative

This is how we’ll formally assess what you have learned in this module.

Referral

This is how we’ll assess you if you don’t meet the criteria to pass this module.