About the project
This project bridges the fields of chemistry and biology to tackle important biomedical challenges. It focuses on the design and synthesis of selective inhibitors targeting the APOBEC3 family of enzymes which are key players in both antiviral defence and cancer mutagenesis.
APOBEC3 enzymes are vital for protecting us against viral infections, yet their off-target gene editing is a major driver of somatic mutations in cancers and viral mutagenesis. In this project, You will design and synthesise novel nucleic acid-based inhibitors to dissect the role of APOBEC3 in tumour evolution and drug resistance, with the aim of providing promising leads for future cancer therapeutics.
We will provide a multidisciplinary, collaborative research environment with access to state-of-the-art facilities. You will also have the option to attend relevant international conferences and training events.
This project provides an excellent opportunity to receive training in nucleic acid chemistry and a range of chemical biology techniques, including:
- protein expression and purification
- human cell culture
- biochemical and cell-based assays to measure APOBEC3 enzyme activity and biological function
