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Research project

Time Travel: Flow sculpting for everyone to make movies of proteins in action

Staff

Lead researcher

Dr Jonathan West

Associate Professor

Research interests

  • Time-Resolved Structural Biology The emergence of serial crystallography brings many exciting possibilities for structural biology but also brings the challenge of preparing many thousands of sub-micron crystals. To address this, we are working with Ivo Tews and Allen Orville to develop high throughput droplet microfluidic systems. Here volumetric confinement of the phase diagram defines growth limits for producing monodisperse protein crystals. Beyond this, the microfluidic processors can be interfaced with the beam line to enable dynamic structural biology.
Connect with Jonathan

Email: J.J.West@soton.ac.uk

Other researchers

Professor Jonathan Essex

Professor
Connect with Jonathan

Email: J.W.Essex@soton.ac.uk

Dr Bram Sengers

Associate Professor
Connect with Bram

Email: B.G.Sengers@soton.ac.uk

Professor Phil Williamson

Head of School

Research interests

  • Molecular processes underpinning neurodegenerative disease
  • Structure and function of cell membranes
  • Development and application of solid-state NMR and other biophysical techniques for the analysis of biological systems
Connect with Phil

Email: P.T.Williamson@soton.ac.uk

Dr Eamonn Reading

Associate Professor-Molecular Bioscience

Research interests

  • Membrane proteins
  • Mass spectrometry
  • Multidrug efflux pumps
Connect with Eamonn

Email: E.Reading@soton.ac.uk

Research outputs